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. Author manuscript; available in PMC: 2023 Oct 14.
Published in final edited form as: Clin Cancer Res. 2023 Apr 14;29(8):1546–1556. doi: 10.1158/1078-0432.CCR-22-3032

Table 1.

Characteristics of Eligible Patients.

Characteristic No. (%)

A3973 (n=34) ANBL0532 (n=27) A3973 + ANBL0532 (n=61) ANBL00B1 [not in A3973 or ANBL0532] (n=72) ANBL14B8 Cohort (n=101)

Age at diagnosis, months (median, range) 40.49
(18.27, 189.08)
33.51
(18.04, 235.30)
37.55
(18.04, 235.30)

36.99
(18.14, 240.23)
36.86
(18.04, 240.23)

A3973 Enrollments 34 (100.00) 0 (0.00) 34 (55.74) -- 6 (5.94)

ANBL0532 Enrollments 0 (0.00) 27 (100.00) 27 (44.26) -- 23 (22.77)

Sex
 • Female 18 (52.94) 17 (62.96) 35 (57.38) 36 (50.00) 53 (52.48)
 • Male 16 (47.06) 10 (37.04) 26 (42.62) 36 (50.00) 48 (47.52)

Primary site
 • Adrenal 6 (18.18) 6 (23.08) 12 (20.34) 13 (18.84) 18 (18.56)
 • Abdominal, other 20 (60.61) 14 (53.85) 34 (57.63) 38 (55.07) 55 (56.70)
 • Neck -- -- -- 3 (4.35) 3 (3.09)
 • Thorax 4 (12.12) 3 (11.54) 7 (11.86) 6 (8.70) 8 (8.25)
 • Other 3 (9.09) 3 (11.54) 6 (10.17) 9 (13.04) 13 (13.40)
 • Unknown 1 1 2 3 4

Response after induction therapy
 • Complete/Very Good Partial Response 20 (64.52) 19 (73.08) 39 (68.42)
 • Partial Response 10 (32.26) 3 (11.54) 13 (22.81)
 • No/Mixed Response -- 1 (3.85) 1 (1.75)
 • Progressive Disease 1 (3.23) 3 (11.54) 4 (7.02)
 • Not Evaluated or Missing 3 1 4

Immunotherapy on ANBL0032 or ANBL0931 3 (8.82) 20 (74.07) 23 (37.70) 16 (22.22) 34 (33.66)

Relapse 7 (20.59) 10 (37.04) 17 (27.87) 12 (16.67) 23 (22.77)
 • Local 1 (2.94) 4 (14.81) 5 (8.20) 4 (5.56) 8 (7.92)
 • Metastatic 5 (14.71) 4 (14.81) 9 (14.75) 7 (9.72) 12 (11.88)
 • Local + Metastatic 1 (2.94) 2 (7.41) 3 (4.92) 1 (1.39) 3 (2.97)

5-year EFS ± standard error 73.0 ± 8.1 61.4 ± 10.2 68.0 ± 6.4 71.1 ± 6.2 67.9 ± 5.3

5-year OS ± standard error 87.9 ± 5.9 73.0 ± 9.2 81.6 ± 5.3 78.8 ± 5.5 77.7 ± 4.7