Table 1.
Characteristics of Eligible Patients.
Characteristic | No. (%) | ||||
---|---|---|---|---|---|
| |||||
A3973 (n=34) | ANBL0532 (n=27) | A3973 + ANBL0532 (n=61) | ANBL00B1 [not in A3973 or ANBL0532] (n=72) | ANBL14B8 Cohort (n=101) | |
| |||||
Age at diagnosis, months (median, range) | 40.49 (18.27, 189.08) |
33.51 (18.04, 235.30) |
37.55 (18.04, 235.30) |
36.99 (18.14, 240.23) |
36.86 (18.04, 240.23) |
| |||||
A3973 Enrollments | 34 (100.00) | 0 (0.00) | 34 (55.74) | -- | 6 (5.94) |
| |||||
ANBL0532 Enrollments | 0 (0.00) | 27 (100.00) | 27 (44.26) | -- | 23 (22.77) |
| |||||
Sex | |||||
• Female | 18 (52.94) | 17 (62.96) | 35 (57.38) | 36 (50.00) | 53 (52.48) |
• Male | 16 (47.06) | 10 (37.04) | 26 (42.62) | 36 (50.00) | 48 (47.52) |
| |||||
Primary site | |||||
• Adrenal | 6 (18.18) | 6 (23.08) | 12 (20.34) | 13 (18.84) | 18 (18.56) |
• Abdominal, other | 20 (60.61) | 14 (53.85) | 34 (57.63) | 38 (55.07) | 55 (56.70) |
• Neck | -- | -- | -- | 3 (4.35) | 3 (3.09) |
• Thorax | 4 (12.12) | 3 (11.54) | 7 (11.86) | 6 (8.70) | 8 (8.25) |
• Other | 3 (9.09) | 3 (11.54) | 6 (10.17) | 9 (13.04) | 13 (13.40) |
• Unknown | 1 | 1 | 2 | 3 | 4 |
| |||||
Response after induction therapy | |||||
• Complete/Very Good Partial Response | 20 (64.52) | 19 (73.08) | 39 (68.42) | ||
• Partial Response | 10 (32.26) | 3 (11.54) | 13 (22.81) | ||
• No/Mixed Response | -- | 1 (3.85) | 1 (1.75) | ||
• Progressive Disease | 1 (3.23) | 3 (11.54) | 4 (7.02) | ||
• Not Evaluated or Missing | 3 | 1 | 4 | ||
| |||||
Immunotherapy on ANBL0032 or ANBL0931 | 3 (8.82) | 20 (74.07) | 23 (37.70) | 16 (22.22) | 34 (33.66) |
| |||||
Relapse | 7 (20.59) | 10 (37.04) | 17 (27.87) | 12 (16.67) | 23 (22.77) |
• Local | 1 (2.94) | 4 (14.81) | 5 (8.20) | 4 (5.56) | 8 (7.92) |
• Metastatic | 5 (14.71) | 4 (14.81) | 9 (14.75) | 7 (9.72) | 12 (11.88) |
• Local + Metastatic | 1 (2.94) | 2 (7.41) | 3 (4.92) | 1 (1.39) | 3 (2.97) |
| |||||
5-year EFS ± standard error | 73.0 ± 8.1 | 61.4 ± 10.2 | 68.0 ± 6.4 | 71.1 ± 6.2 | 67.9 ± 5.3 |
| |||||
5-year OS ± standard error | 87.9 ± 5.9 | 73.0 ± 9.2 | 81.6 ± 5.3 | 78.8 ± 5.5 | 77.7 ± 4.7 |