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. 2023 Apr 16;13:6190. doi: 10.1038/s41598-023-33269-x

Table 4.

Perioperative outcomes between learning curve phases in LPD and RPD.

LPD RPD
PCL phase ALC phase p value PCL phase ALC phase p value
Patients, n 13 26 18 57
PPPD/whipple 10/3 22/4 0.67 15/3 49/8 0.72
Operative time, min 377 (354–454) 289 (257–307)  < 0.001 381 (340–407) 286 (252–313)  < 0.001
Blood loss, mL 200 (0–350) 50 (0–200) 0.12 100 (100–100) 100 (0–100) 0.14
Open conversion 1 (8%) 2 (8%)  > 0.99 0 2 (4%)  > 0.99
Harvested lymph nodes, n 17 (7.5–22.5) 14.5 (9–21.3) 0.73 14.5 (8–21) 13 (10–19) 0.96
CD grade 0.11 0.85
 0 4 (31%) 12 (46%) 10 (56%) 29 (51%)
 I 2 (15%) 3 (12%) 0 5 (9%)
 II 1 (8%) 9 (35%) 5 (28%) 12 (21%)
 IIIa 3 (23%) 1 (4%) 2 (11%) 7 (12%)
 IIIb 1 (8%) 0 0 0
 IVa 1 (8%) 1 (4%) 1 (6%) 2 (4%)
 IVb 1 (8%) 0 0 1 (2%)
 V 0 0 0 1 (2%)
Major complication, CD ≧ III 6 (46%) 2 (8%) 0.01 3 (17%) 12 (21%)  > 0.99
POPF 0.41 0.21
 Biochemical 2 (15%) 9 (35%) 8 (44%) 24 (42%)
 B 3 (23%) 6 (23%) 1 (6%) 10 (18%)
 C 0 0 1 (6%) 0
DGE, grade B + C 3 (23%) 1 (4%) 0.10 2 (11%) 7 (12%)  > 0.99
PPH, grade B + C 2 (15%) 2 (8%) 0.59 3 (17%) 6 (11%) 0.44
Bile leak 3 (23%) 0 0.03 0 5 (9%) 0.33
Fluid collection 4 (31%) 2 (8%) 0.15 2 (11%) 11 (19%) 0.72
Wound infection 5 (38%) 2 (8%) 0.03 1 (6%) 8 (14%) 0.68
Reoperation 1 (8%) 0 0.33 0 1 (2%)  > 0.99
Hospital stay, days 17 (12.5–30) 15 (12–20) 0.26 13 (11–16.3) 15 (11–23) 0.53
Re-admission 2 (15%) 0 0.11 3 (17%) 5 (9%) 0.39

PLC pre-learning curve, ALC after-learning curve, PPPD pylorus preserving pancreaticoduodenectomy, CD Clavien–Dindo, DGE delayed gastric emptying, PPH postpancreatectomy hemorrhage, POPF postoperative pancreatic fistula.