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. 2023 Apr 16;13:6190. doi: 10.1038/s41598-023-33269-x

Table 5.

Perioperative outcomes between approaches in the PLC and ALC phase.

PLC phase ALC phase
LPD RPD p value LPD RPD p value
Patients, n 13 18 26 57
PPPD/whipple 10/3 15/3 0.68 22/4 49/8  > 0.99
Operative time, min 377 (354–454) 381 (340–407) 0.56 289 (257–307) 286 (252–313) 0.91
Blood loss, mL 200 (0–350) 100 (100–100) 0.85 50 (0–200) 100 (0–100) 0.63
Open conversion 1 (8%) 0 0.42 2 (8%) 2 (4%) 0.59
Harvested lymph nodes, n 17 (7.5–22.5) 14.5 (8–21) 0.62 14.5 (9–21.3) 13 (10–19) 0.69
CD grade 0.18 0.63
 0 4 (31%) 10 (56%) 12 (46%) 29 (51%)
 I 2 (15%) 0 3 (12%) 5 (9%)
 II 1 (8%) 5 (28%) 9 (35%) 12 (21%)
 IIIa 3 (23%) 2 (11%) 1 (4%) 7 (12%)
 IIIb 1 (8%) 0 0 0
 IVa 1 (8%) 1 (6%) 1 (4%) 2 (4%)
 IVb 1 (8%) 0 0 1 (2%)
 V 0 0 0 1 (2%)
Major complication, CD ≧ III 6 (46%) 3 (17%) 0.11 2 (8%) 12 (21%) 0.53
POPF 0.18 0.44
 Biochemical 2 (15%) 8 (44%) 9 (35%) 24 (42%)
 B 3 (23%) 1 (6%) 6 (23%) 10 (18%)
 C 0 1 (6%) 0 0
DGE, grade B + C 3 (23%) 2 (11%) 0.63 1 (4%) 7 (12%) 0.71
PPH, grade B + C 2 (15%) 3 (17%)  > 0.99 2 (8%) 6 (11%)  > 0.99
Bile leak 3 (23%) 0 0.06 0 5 (9%) 0.17
Fluid collection 4 (31%) 2 (11%) 0.21 2 (8%) 11 (19%) 0.21
Wound infection 5 (38%) 1 (6%) 0.06 2 (8%) 8 (14%) 0.49
Reoperation 1 (8%) 0 0.42 0 1 (2%)  > 0.99
Hospital stay, days 17 (12.5–30) 13 (11–16.3) 0.09 15 (12–20) 15 (11–23) 0.90
Re-admission 2 (15%) 3 (17%)  > 0.99 0 5 (9%) 0.17

PLC pre-learning curve, ALC after-learning curve, PPPD pylorus preserving pancreaticoduodenectomy, CD Clavien–Dindo, DGE delayed gastric emptying, PPH postpancreatectomy hemorrhage, POPF postoperative pancreatic fistula.