Fig. 3.

Example of distortion correction with Synth compared to rigid-body alignment(a) Parasagittal slice of T2w image from an example MSC participant. Fuschia and blue lines indicate gray/white matter boundary estimated by freesurfer segmentation of the associated T1w image. (b) Corresponding slice of functional EPI image aligned to the anatomical image using rigid body alignment procedure implemented in FSL’s FLIRT. Red arrows indicate regions of local misalignment due to image distortion. Red dots indicate anatomical fiducial markers to aid in assessing distortion correction applied to cerebellum and pons. (c) Identical slice through EPI image corrected using Synth. Note improved local alignment of corpus callosum, occipital pole, pons, and orbitofrontal cortex. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)