Table 2.
Summary of IC50 values of inhibitory in vitro activity against SARS-CoV-2 PLpro of the 13 hit compounds using an enzymatic assay. mean ± SD (n = 3).
| Compound (ug/mL) | SARS-CoV-2 PLpro (0.5 ng/μl) |
|---|---|
| GRL0617 | 1.113 ± 0.175 |
| SIMR1440 | 4.117 + 1.410 |
| SIMR1473 | ND |
| SIMR1489 | 33.224 + 5.78 |
| SIMR1493 | 0.0659 ± 0.0071 |
| SIMR1783 | 27.577 ± 2.27 |
| SIMR1888 | 4.094 ± 2.40 |
| SIMR1911 | ND |
| SIMR2304 | ND |
| SIMR2593 | 0.852 ± 0.89 |
| SIMR3030 | 0.0399 ± 0.081 |
| SIMR7088 | 6.0726 ± 0.65 |
| SIMR7109 | 12.8315 ± 2.057 |
| SIMR7111 | 13.947 ± 0.69 |
ND: Not Determined.