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Half maximal cytotoxic concentration (CC50), inhibitory concentration 50 (IC50) and selectivity index (CC50/IC50) against SARS-CoV-2 and MERS-CoV for the tested compounds.
| Compound | CC50 (Vero E6) | IC50 (SARS-CoV-2) | SI | IC50 (MERS-CoV) | SI |
|---|---|---|---|---|---|
| SIMR3030 | 55.63 μg/mL | 12.10 μg/mL | 4.60 | 6.206 μg/mL | 8.96 |
| SIMR1911 | 89.67 μg/mL | 216.9 μg/mL | 0.41 | ND | NA |
| SIMR1493 | 43.12 μg/mL | 67.63 μg/mL | 0.64 | ND | NA |
ND: Not Done; NA: Not Applicable.
