Table 4.
In vitro physicochemical ADME data.
| Compound | Max Aq. Sol. (μM) | Permeability (10−6 cm/s) | % Recovery | Stability MLMa t1/2, min | Stability HLMb t1/2, min | Mic. Control Mouse % @ 60 minc | Mic. Control Human % @ 60 minc | CYP3A4 IC50 (μM) | CYP2D6 IC50 (μM) | CYP2C9 IC50 (μM) |
|---|---|---|---|---|---|---|---|---|---|---|
| SIMR-1493 | 56.1 | Not tested | Not tested | 11.2 | 5.7 | 92 | 119 | 134 | >10,000 | >10,000 |
| SIMR-3030 | 166 | 5.90 ± 0.3 | 77 ± 0.7 | >60 | >60 | 108 | 102 | >10,000 | >10,000 | >10,000 |
a
MLM = Mouse Liver Microsomes.
b
HLM = Human Liver Microsomes.
c
Assay carried out without NADPH; percent remaining after 60-min incubation.