TABLE 2.
Effects and significance for the 16 metabolites that were significant after metabolome-wide FDR correction in the ADAD versus CO comparisons and at least nominally significant in the sAD versus CO and TREM2 versus CO comparisons in the WUSM cohort
| Metabolite | ADAD vs. CO |
sAD vs. CO |
TREM2 vs. CO |
ROSMAP(DLPFC Metabolon) |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Effect | P-value | q-valuea | Effect | P-value | Effect | P-value | Effect | P-value | |
| Aspartate | 0.160 | 1.1 × 10−3 | 1.1 × 10−2 | 0.085 | 2.2 × 10−3 | 0.123 | 6.0 × 10−3 | 0.042 | 1.1 × 10−2 |
| γ-glutamylthreonine | 0.263 | 3.2 × 10−3 | 2.3 × 10−2 | 0.171 | 5.4 × 10−4 | 0.278 | 7.1 × 10−4 | 0.095 | 5.1 × 10−4 |
| β-citrylglutamate | −0.217 | 4.9 × 10−5 | 2.2 × 10−3 | −0.148 | 2.1 × 10−4 | −0.293 | 7.8 × 10−7 | −0.062 | 3.7 × 10−4 |
| Glutamate | 0.086 | 7.1 × 10−3 | 3.9 × 10−2 | 0.048 | 1.7 × 10−2 | 0.071 | 6.5 × 10−3 | 0.060 | 1.1 × 10−8 |
| N-acetylglutamate | −0.207 | 1.7 × 10−5 | 1.0 × 10−3 | −0.080 | 2.7 × 10−3 | −0.122 | 3.2 × 10−3 | −0.033 | 6.8 × 10−4 |
| Ergothioneine | −0.255 | 8.3 × 10−3 | 4.3 × 10−2 | −0.213 | 8.0 × 10−5 | −0.274 | 7.5 × 10−3 | −0.092 | 2.5 × 10−2 |
| 3-hydroxy-2-ethylpropionate | 0.177 | 2.0 × 10−3 | 1.7 × 10−2 | 0.099 | 4.4 × 10−2 | 0.195 | 8.7 × 10−3 | ||
| 1,5-anhydroglucitol (1,5-AG) | 0.310 | 6.6 × 10−6 | 7.3 × 10−4 | 0.131 | 1.1 × 10−2 | 0.155 | 4.3 × 10−2 | 0.088 | 4.4 × 10−3 |
| 2-methylcitrate/homocitrate | −0.171 | 1.3 × 10−3 | 1.2 × 10−2 | −0.087 | 1.3 × 10−2 | −0.118 | 2.9 × 10−2 | −0.048 | 1.1 × 10−2 |
| Glutarate (C5-DC) | 0.252 | 7.3 × 10−5 | 2.3 × 10−3 | 0.121 | 5.7 × 10−3 | 0.170 | 1.6 × 10−2 | 0.090 | 1.5 × 10−5 |
| CDP-choline | −0.095 | 9.6 × 10−4 | 1.0 × 10−2 | −0.040 | 4.6 × 10−2 | −0.093 | 1.6 × 10−3 | 0.042 | 7.5 × 10−3 |
| CDP-ethanolamine | −0.102 | 6.1 × 10−4 | 7.7 × 10−3 | −0.054 | 2.8 × 10−3 | −0.128 | 1.8 × 10−4 | −0.024 | 8.2 × 10−2 |
| Glycerophosphoinositol | −0.164 | 3.4 × 10−4 | 5.3 × 10−3 | −0.095 | 1.3 × 10−3 | −0.098 | 2.7 × 10−2 | −0.021 | 4.5 × 10−2 |
| Nicotinamide (vitamin B3) | −0.066 | 6.8× 10−3 | 3.7 × 10−2 | −0.032 | 1.9 × 10−2 | −0.056 | 9.4 × 10−3 | 0.008 | 0.33 |
| α-tocopherol (vitamin E) | −0.120 | 4.1 × 10−5 | 2.0 × 10−3 | −0.065 | 1.5 × 10−3 | −0.115 | 1.8 × 10−5 | −0.123 | 3.0 × 10−5 |
| Retinol (vitamin A) | −0.287 | 1.3 × 10−5 | 9.2 × 10−4 | −0.156 | 8.0 × 10−4 | −0.192 | 1.4 × 10−3 | −0.196 | 2.9E-04 |
Note: Highlighted in bold are metabolites with significant metabolome-wide FDR-adjusted q-values in each group (see Table S6 for metabolome-wide sAD, TREM2, and ROSMAP q-values).
a
q-value represents metabolome-wide FDR adjusted significance for 627 metabolites.