Table 1:
Relaxivity constants for Feraheme, MoldayION, and generic ferumoxytol in normal saline, human plasma, and human whole blood at 3.0T (22° C).
| Contrast | Medium | r1 relaxivity (mM−1s−1) | SE | R2 | r2 relaxivity (mM−1s−1) | SE | R2 |
|---|---|---|---|---|---|---|---|
|
| |||||||
| Feraheme (AMAG) | Saline | 7.11 | 0.13 | 1.00 | 111.74 | 3.76 | 1.00 |
| Plasma | 7.83 | 0.07 | 1.00 | 98.61 | 0.92 | 1.00 | |
| Blood | 6.68 | 0.20 | 1.00 | 123.60 | 5.22 | 1.00 | |
|
| |||||||
| MoldayION (BioPal) | Saline | 8.62 | 0.16 | 1.00 | 109.68 | 2.56 | 1.00 |
| Plasma | 9.14 | 0.47 | 0.99 | 112.35 | 2.88 | 1.00 | |
| Blood | 7.55 | 0.21 | 1.00 | 138.02 | 8.90 | 0.99 | |
|
| |||||||
| Generic Ferumoxytol (Sandoz) | Saline | 8.30 | 0.29 | 1.00 | 105.07 | 2.20 | 1.00 |
| Plasma | 8.30 | 0.17 | 1.00 | 101.11 | 0.24 | 1.00 | |
| Blood | 7.30 | 0.22 | 1.00 | 129.64 | 8.70 | 0.99 | |
Note: ΔR1 = r1*C and ΔR2 = r2*C, where r1 and r2 are the relaxivity constants (mM−1s−1) and C is the iron concentration (mM). A two-way analysis of covariance (ANCOVA) found a significant difference in the variance of R1 (p<0.001) or R2 (p=0.001) among the three contrast agents. SE, standard error.