Table 2:

SNR and CNR of HASTE and VIBE images with Feraheme, MoldayION, and Generic Ferumoxytol contrast.

Signal-to-noise ratio (SNR)
	T2w HASTE*			T1w VIBE*
Tissue	Feraheme	Molday ION	Generic Ferumoxytol	Feraheme	Molday ION	Generic Ferumoxytol
Blood	8.3	8.6±4.0	9.6	482.8	459.1±171.8	723.9
Muscle	69.9	57.5±33.9	72.9	147.4	123.9±41.2	127.2
Liver	6.3	8.8±5.8	7.3	310.3	317.5±149.6	365.1
Spleen	34.8	49.6±45.7	83.4	261.8	285.9±128.9	279.2
Contrast-to-noise ratio (CNR)
	T2w HASTE*			T1w VIBE*
Tissue	Feraheme	Molday ION	Generic Ferumoxytol	Feraheme	Molday ION	Generic Ferumoxytol
Muscle	61.6	48.9±32.7	66.4	−335.3	−335.2±133.8	−596.8
Liver	−2.0	0.1±5.6	0.8	−172.5	−141.6±29.9	−358.9
Spleen	26.5	41±45.5	76.8	−221.0	−173.2±52.5	−444.8

^*SNR of blood pool (descending aorta), longissimus (skeletal) muscle, liver, and spleen from regions of interest drawn on coronal HASTE and axial VIBE images. The Feraheme, MoldayION, and generic ferumoxytol contrast dose was 4.0 mg/kg. CNR of longissimus muscle, liver, and spleen relative to blood pool were calculated based on signal intensity measurements from regions of interest on post-contrast HASTE and VIBE images.

Mean SNR and CNR reported in Feraheme (N = 1 swine) and Generic Ferumoxytol (N = 1) cohorts; SNR and CNR reported as mean ± SD in MoldayION cohort (N = 16 swine).

HASTE, Half-Fourier-Acquired Single-shot Turbo spin Echo; VIBE, Volumetric Interpolated Breath-hold Exam