Table 1.
Clinicodemographic characteristics of acute ischemic stroke patientsa.
| Characteristic | HT (n = 54) | No HT (n = 264) | P |
|---|---|---|---|
| Age (years) | 76 (63–83) | 70 (60–79) | 0.016 |
| Sex (female) | 23 (42.5) | 84 (31.8) | 0.127 |
| Hypertension | 43 (79.6) | 201 (76.1) | 0.581 |
| Diabetes mellitus | 14 (25.9) | 85 (32.2) | 0.365 |
| Hyperlipidemia | 15 (27.7) | 110 (41.7) | 0.057 |
| Atrial fibrillation | 36 (66.7) | 67 (25.4) | <0.001 |
| Coronary heart disease | 5 (9.2) | 24 (9.1) | 0.969 |
| Previous stroke history | 6 (11.1) | 35 (13.3) | 0.669 |
| Smoking history | 8 (14.8) | 66 (25.0) | 0.107 |
| Drinking history | 13 (24.0) | 55 (20.8) | 0.597 |
| Previous antithrombotic therapy | 6 (11.1) | 33 (12.5) | 0.777 |
| Time from onset to thrombolysis (min) | 160 (120–193) | 170 (120–210) | 0.411 |
| NIHSS score (points) | 11 (7–17) | 6 (4–10) | <0.001 |
| Systolic blood pressure level (mmHg) | 162 (141–180) | 159 (142–173) | 0.360 |
| Diastolic blood pressure (mmHg) | 92 (81–104) | 87 (78–97) | 0.045 |
| Blood glucose level (mmol/L) | 7.3 (6.1–9.4) | 7.0 (6.0–8.8) | 0.345 |
| Platelet count (109/L) | 181 (155–216) | 190 (165–227) | 0.066 |
| INR | 1.04 (1.01–1.10) | 1.02 (0.97–1.09) | 0.007 |
| APTT (sec) | 33.8 (31.2–36.7) | 33.9 (31.0–36.8) | 0.802 |
| Total cholesterol (mmol/L) | 4.3 (3.7–4.8) | 4.4 (3.7–5.1) | 0.419 |
| Low-density lipoprotein cholesterol (mmol/L) | 2.5 (1.9–3.1) | 2.6 (2.0–3.3) | 0.409 |
| TOAST classification | <0.001 | ||
| Large artery atherosclerosis | 14 (25.9) | 76 (28.8) | |
| Cardioembolism | 31 (57.4) | 70 (26.5) | |
| Small-artery occlusion | 4 (7.4) | 75 (28.4) | |
| Stroke of other determined cause | 2 (3.7) | 5 (1.9) | |
| Stroke of undetermined cause | 3 (5.6) | 38 (14.4) | |
| Anterior leukoaraiosis | |||
| 0 | 20 (37.0) | 139 (52.7) | 0.010 |
| 1 | 25 (46.3) | 103 (39.0) | |
| 2 | 9 (16.7) | 22 (8.3) | |
| Posterior leukoaraiosis | |||
| 0 | 23 (42.6) | 172 (65.2) | 0.001 |
| 1 | 21 (38.9) | 61 (23.1) | |
| 2 | 10 (18.5) | 31 (11.7) | |
| Severe anterior or posterior leukoaraiosis | 14 (25.9) | 40 (15.2) | 0.002 |
| Cortical atrophy | |||
| 0 | 6 (11.1) | 65 (24.6) | <0.001 |
| 1 | 29 (53.7) | 166 (62.9) | |
| 2 | 19 (35.2) | 33 (12.5) | |
| Central atrophy | |||
| 0 | 10 (18.5) | 106 (40.2) | <0.001 |
| 1 | 27 (50.0) | 129 (48.9) | |
| 2 | 17 (31.5) | 29 (11.0) | |
| Severe cortical or central atrophy | 26 (48.1) | 45 (17.0) | <0.001 |
| Lacune | |||
| 0 | 28 (51.9) | 142 (53.8) | 0.984 |
| 1 | 17 (25.9) | 70 (26.5) | |
| ≥2 | 9 (22.2) | 52 (19.7) | |
| Total CSVD score | |||
| 0 | 19 (35.2) | 166 (62.9) | <0.001 |
| 1 | 19 (35.2) | 62 (23.5) | |
| 2 | 14 (25.9) | 33 (12.5) | |
| 3 | 2 (3.7) | 3 (1.1) | |
| Total CSVD score ≥ 1 | 35 (64.8) | 98 (37.1) | <0.001 |
Values are n (%) or median (interquartile range), unless otherwise noted. Boldfaced values differ significantly between the two groups.
a
Mann-Whitney U test.
HT, hemorrhagic transformation; APTT, activated partial thromboplastin time; INR, international normalized ratio; NIHSS, National Institutes of Health Stroke Scale; CSVD, cerebral small vessel disease.