Table 4.
New progress of microfluidic chips.
| Research purpose | Innovation | Results | Ref. |
|---|---|---|---|
| Cancer cell migration model | 3D collagen barrier is formed through polyelectrolyte composite solidification process | Form 3D aggregates of cells similar to cancer tumors, mimicking the migration of cancer cells in vivo | (106) |
| Microarray cell culture system | 1156 square microcontainers, large capacity, to ensure nutrient supply external bioreactor | Preserve the function of rat primary hepatocytes for more than 2 weeks | (107) |
| New microfluidic platform | The microfluidic platform can realize the microfluidic control with many repetitions and long duration | High-throughput production of tumors of uniform size; Various 3D tumor microspheres produced in the device | (108) |
| New cell culture methods | Gelatin-based 384-well ready-to-use microscaffold array | It is suitable for a variety of tumor cells and can be used for drug resistance detection and tumor cell culture | (109) |
| New manufacturing of cell sphere | Construct a multicellular culture platform using acoustic fluid | This produces more than 6000 tumor spheres per operation and shortens the tumor sphere formation time to one day. | (110) |
| New microfluidic chip | Polydimethylsiloxane is made of a double casting technique with a thermal aging step | The tumor microsphere culture time of up to 4 weeks can observe the reaction of tumor microsphere for a long time | (111) |
| Novel TME model | Cancer cells in the microcapsule were encapsulated with a hydrogel shell to form a 3D vascularized tumor | The angiogenesis in the 3D microenvironment of human tumor was simulated | (112) |
| New 3D co-culture model | Panc-1 tumor spheres were co-cultured with pancreatic stellate cells using microarray chips and | The role of pancreatic stellate cells in tumor development and metastasis was studied | (113) |