TABLE 1.
Mean ± SD (n = 9) for CRH (ng/mL), Dopamine (DA) (pg/mL), ACTH (pmol/L) and cortisol (nmol/L) in control (C), wound (W) and wound + stress (WS) during an 8-week experimental timespan (primary stress response).
| Group | Pre-stress | Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | |
|---|---|---|---|---|---|---|---|---|---|---|
| M ± SD | M ± SD | M ± SD | M ± SD | M ± SD | M ± SD | M ± SD | M ± SD | M ± SD | ||
| CRH (ng/mL) | C | 1.48 ± 0.29 | 1.73 ± 0.51 | 1.75 ± 0.53 | 1.51 ± 0.36a | 1.60 ± 0.43 | 1.36 ± 0.57 | 2.49 ± 0.86*a | 3.13 ± 2.46*a | 3.70 ± 3.18* |
| W | 1.62 ± 0.24 | 1.77 ± 0.25 | 2.01 ± 1.09ab | 1.65 ± 0.41 | 1.78 ± 0.77 | 1.65 ± 0.56ab | 1.91 ± 1.91b | 3.46 ± 3.41 | ||
| WS | 1.78 ± 0.28 | 1.78 ± 0.28 | 5.44 ± 6.10*b | 2.71 ± 1.63* | 1.83 ± 0.99 | 1.28 ± 0.44b | 1.71 ± 0.66ab | 2.56 ± 1.34 | ||
| DA (pg/mL) | C | 243.4 ± 18.0 | 292.2 ± 62.7ab | 267.5 ± 41.0 | 278.3 ± 26.4* | 292.7 ± 61.4 | 303.5 ± 48.0*ab | 329.0 ± 48.8*ab | 301.5 ± 21.1*a | 427.1 ± 109.8* |
| W | 302.6 ± 39.8*a | 293.5 ± 22.5* | 285.6 ± 21.0* | 305.3 ± 57.4* | 324.7 ± 37.7*a | 347.9 ± 30.9*a | 365.7 ± 68.8*b | 391.8 ± 80.2* | ||
| WS | 253.7 ± 45.5b | 272.8 ± 45.9 | 281.4 ± 26.2* | 277.8 ± 33.4 | 282.0 ± 16.5*b | 304.1 ± 17.2*b | 300.2 ± 22.6*a | 385.6 ± 49.0* | ||
| ACTH (pmol/L) | C | 34.46 ± 4.14 | 44.83 ± 3.69* | 39.28 ± 9.35 | 41.99 ± 6.48 | 52.84 ± 8.50*a | 55.93 ± 12.37*a | 47.63 ± 9.32a | 55.22 ± 14.01a | 50.35 ± 4.38a |
| W | 44.6 ± 6.91* | 45.53 ± 7.98* | 43.73 ± 10.10 | 52.94 ± 9.04*a | 47.99 ± 6.13a | 76.64 ± 29.00*b | 83.42 ± 36.66*ab | 62.48 ± 12.84*ab | ||
| WS | 39.93 ± 6.66 | 51.09 ± 9.30* | 48.53 ± 4.35* | 198.95 ± 81.55*b | 124.39 ± 78.72*b | 79.31 ± 6.10*b | 132.5 ± 98.76*b | 72.33 ± 25.40*b | ||
| Cortisol (nM) | C | 15.12 ± 14.87 | 18.66 ± 38.77 | 16.91 ± 28.29 | 9.74 ± 16.21 | 9.50 ± 14.02 | 17.14 ± 19.64 | 3.46 ± 3.60a | 1.68 ± 0.00a | 1.68 ± 0.00a |
| W | 4.54 ± 7.08 | 5.08 ± 10.19* | 11.26 ± 28.75 | 8.97 ± 18.12 | 5.46 ± 11.11 | 9.54 ± 15.08a | 20.67 ± 30.37a | 10.52 ± 14.60a | ||
| WS | 31.92 ± 40.60 | 5.07 ± 10.15* | 11.19 ± 28.53 | 39.44 ± 69.90 | 40.14 ± 43.61 | 80.89 ± 36.81*b | 71.51 ± 62.77b | 93.38 ± 98.58*b | ||
C = Control, W = Wound, WS = Wound and Stress. Values represent means ± SD, n = 9 per treatment/week. Means in a column (week) within the same measurement that have differing superscript letters a-b indicate significant differences (p < 0.05). Asterisks* show a significant difference compared to the Pre-stress group (p < 0.05).