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. 2023 Apr 3;14:1147235. doi: 10.3389/fphys.2023.1147235

TABLE 2.

Mean ± SD (n = 9) of glucose (mM), lactate (mM), magnesium (mM), calcium (mM) and osmolality (mOsm/kg) in control (C), wound (W) and wound + stress (WS) during an 8-week experimental timespan (secondary stress responses).

Group Pre-stress Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8
M ± SD M ± SD M ± SD M ± SD M ± SD M ± SD M ± SD M ± SD M ± SD
Glucose (mM) C 2.71 ± 0.13 3.66 ± 0.38* 3.78 ± 0.82* 3.43 ± 0.37* 3.32 ± 0.47* 3.52 ± 0.39* 3.49 ± 0.22* 3.58 ± 0.39* 3.68 ± 0.43*
W 4.07 ± 0.72* 3.32 ± 0.32* 3.44 ± 0.34* 4.06 ± 1.14* 3.27 ± 0.30* 3.63 ± 0.43* 3.57 ± 0.48* 3.48 ± 0.16*
WS 4.03 ± 0.84* 3.54 ± 0.49* 3.58 ± 0.32* 3.44 ± 0.38* 3.43 ± 0.30* 3.64 ± 0.26* 3.69 ± 0.64* 3.82 ± 0.41*
 Lactate (mM) C 3.23 ± 0.69 3.67 ± 0.97 3.71 ± 1.02 3.99 ± 0.74 4.60 ± 0.71* 4.39 ± 0.97* 4.62 ± 1.09* 4.79 ± 0.81* 5.73 ± 0.90*a
W 4.56 ± 1.87 3.71 ± 1.17 5.08 ± 1.35* 4.34 ± 1.05* 3.72 ± 0.65 5.12 ± 2.04* 5.14 ± 1.45* 4.27 ± 0.65*b
WS 4.33 ± 1.31 4.20 ± 1.29 4.89 ± 1.53* 4.14 ± 0.51* 3.41 ± 0.58 5.29 ± 1.27* 4.54 ± 1.57 4.87 ± 0.99*ab
 Magnesium (mM) C 1.20 ± 0.35 1.18 ± 0.17 1.43 ± 0.41a 1.12 ± 0.28 1.02 ± 0.24 1.05 ± 0.13 0.96 ± 0.31a 1.45 ± 0.47 1.44 ± 0.38ab
W 1.41 ± 0.35 1.01 ± 0.23b 1.29 ± 0.34 1.17 ± 0.28 1.14 ± 0.28 1.60 ± 0.30*b 1.50 ± 0.33 1.75 ± 0.25*a
WS 1.34 ± 0.49 1.07 ± 0.16b 1.40 ± 0.36 1.14 ± 0.20 1.06 ± 0.20 1.40 ± 0.41*b 1.22 ± 0.43 1.17 ± 0.34b
 Calcium (mM) C 3.17 ± 0.29 3.42 ± 0.25 3.49 ± 0.36 3.29 ± 0.20 3.24 ± 0.37 3.31 ± 0.15 2.97 ± 0.65a 3.54 ± 0.27 3.53 ± 0.30*a
W 3.32 ± 0.36 3.19 ± 0.39 3.40 ± 0.31 3.29 ± 0.25 3.23 ± 0.43 3.61 ± 0.19b 3.49 ± 0.26 3.76 ± 0.22*a
WS 3.22 ± 0.33 3.19 ± 0.21 3.46 ± 0.23 3.33 ± 0.24 3.32 ± 0.17 3.39 ± 0.25ab 3.10 ± 0.59 3.18 ± 0.35*b
 Chloride (mM) C 133.1 ± 5.9 128.1 ± 8.7*a 131.4 ± 20.8 115.4 ± 13.2*a 120.4 ± 12.3*ab 106.9 10.2*a 117.9 ± 11.5* 112.8 ± 7.0* 108.9 ± 12.4*a
W 108.8 ± 10.7*b 116.8 ± 10.4 103.8 ± 12.3*a 109.3 ± 12.8*a 114.7 ± 13.5*a 119.9 ± 14.4 119.6 ± 7.0* 116.4 ± 15.3*a
WS 126.8 ± 11.2*a 125.2 ± 10.1 130.9 ± 10.2*b 131.3 ± 14.0*b 128.4 ± 6.4b 125.8 ± 12.1 117.6 ± 13.8* 131.3 ± 6.7b
 Osmolality (mOsm/Kg) C 408.3 ± 25.7 348.8 ± 10.3*a 381.3 ± 41.6 403.3 ± 37.9 416.6 ± 30.1 429.7 ± 30.9 433.9 ± 38.0 448.1 ± 39.3* 437.8 ± 27.1a
W 389.1 ± 28.7b 399.7 ± 40.2 427.6 ± 37.1 417.6 ± 30.7 441.8 ± 81.0 466.7 ± 56.3* 432.0 ± 26.5 418.6 ± 29.0ab
WS 393.9 ± 32.2b 402.3 ± 28.1 400.0 ± 30.7 406.4 ± 30.9 398.2 ± 29.9 435.7 ± 34.3 413.8 ± 32.2 403.2 ± 21.8b

C = Control, W = Wound, WS = Wound and Stress. Values represent means ± SD, n = 9 per treatment/week. Means in a column (week) within the same measurement that have differing superscript letters a-b indicate significant differences (p < 0.05). Asterisks* show a significant difference compared to the Pre-stress group (p < 0.05).