Table 1.
Baseline characteristics and events of cohort 1.
| Categories | Low SHR n=2604 | High SHR n=1283 | P value |
|---|---|---|---|
| Demographic | |||
| Age, year | 63.3 ± 14.8 | 63.1 ± 14.5 | 0.62 |
| Sex, male, n (%) | 1563 (60.0) | 709 (55.3) | 0.005 |
| Body mass index, kg/m2 | 28.4 ± 5.3 | 28.4 ± 5.6 | 0.75 |
| Comorbidities | |||
| CHD, n (%) | 1142 (43.9) | 428 (33.4) | <0.001 |
| CKD, n (%) | 500 (19.2) | 284 (22.1) | 0.032 |
| COPD, n (%) | 32 (1.2) | 27 (2.1) | 0.036 |
| Hypertension, n (%) | 804 (30.9) | 306 (23.9) | <0.001 |
| Prediabetes, n (%) | 29 (1.1) | 9 (0.7) | 0.22 |
| Diabetes, n (%) | 1073 (41.2) | 607 (47.3) | <0.001 |
| Laboratory tests | |||
| Creatinine, μmol/L | 0.9 (0.7, 1.3) | 1.1 (0.8, 1.6) | <0.001 |
| Glucose, mmol/L | 115.0 (99.0, 133.0) | 189.0 (156.0, 255.0) | <0.001 |
| HbA1c | 5.9 (5.5, 6.8) | 5.8 (5.3, 6.6) | <0.001 |
| LDL, mg/dL | 81.0 (72.0, 93.0) | 81.0 (73.0, 82.0) | 0.016 |
| ALT, U/L | 27.0 (25.0, 27.0) | 27.0 (24.0, 46.0) | <0.001 |
| AST, U/L | 38.0 (33.0, 38.0) | 38.0 (35.0, 72.0) | <0.001 |
| HGB, mg/dL | 11.5 (10.0, 13.1) | 11.5 (9.8, 13.3) | 0.72 |
| Plt, K/μL | 210.0 (159.0, 270.0) | 216.0 (163.0, 281.0) | 0.055 |
| WBC, K/μL | 12.2 (9.0, 16.7) | 13.7 (9.9, 18.1) | <0.001 |
| ICU admission | |||
| OASIS score | 31.0 (25.0, 37.0) | 34.0 (27.0, 41.0) | <0.001 |
| LODS score | 4.0 (2.0, 6.0) | 5.0 (3.0, 8.0) | <0.001 |
| APSIII score | 40.0 (29.0, 54.0) | 49.0 (35.0, 68.0) | <0.001 |
| SIRS score | 2.0 (2.0, 3.0) | 3.0 (2.0, 3.0) | <0.001 |
| SOFA score | 3.0 (1.0, 5.0) | 3.0 (2.0, 6.0) | <0.001 |
| MELD score | 11.0 (8.0, 17.0) | 13.0 (9.0, 20.9) | <0.001 |
| First Care Unit | <0.001 | ||
| CVICU | 901 (34.6) | 207 (16.1) | |
| CCU | 383 (14.7) | 250 (19.5) | |
| MICU/SICU | 919 (35.3) | 623 (48.6) | |
| NSICU | 207 (7.9) | 77 (6.0) | |
| TSICU | 194 (7.5) | 126 (9.8) | |
| Vital signs | |||
| Heart rate, bmp | 82.0 (71.0, 93.0) | 84.0 (73.0, 96.0) | <0.001 |
| SBP, mmHg | 118.0 (111.0, 125.0) | 118.0 (113.0, 126.0) | 0.25 |
| DBP, mmHg | 61.0 (57.0, 65.0) | 61.0 (57.0, 65.0) | 0.99 |
| SpO2, % | 97.0 (96.0, 98.0) | 97.0 (96.0, 98.0) | 0.67 |
| Events | |||
| LOS ICU, days | 2.7 (1.6, 5.1) | 3.9 (2.1, 7.6) | <0.001 |
| ICU death, n (%) | 74 (2.8) | 102 (8.0) | <0.001 |
SHR, stress hyperglycemia ratio; CHD, coronary heart disease; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; HbA1c, hemoglobin a1c; LDL, low density lipoprotein; ALT, alanine transaminase; AST, aspartate aminotransferase; HGB, hemoglobin; WBC, white blood cell; ICU, intensive care unit; SOFA, sequential organ failure assessment; LODS, logistic organ dysfunction system; SIRS, systemic inflammatory response syndrome; OASIS, Oxford acute severity score; APS III, acute physiology score III; MELD, model for end-stage liver disease; CCU, coronary care unit; CVICU, cardiovascular intensive care unit; MICU/SICU, medical intensive care unit/surgical intensive care unit; TSICU, trauma/surgical intensive care unit; NSICU, neurosurgical intensive care unit.