Table 1.
General characteristics of HBsAg-positive adults with different levels of serum HBV-DNA.
| Characteristics | Overall (N=12,527) |
<100 IU/mL (N=5,285) |
≥100, <2000 IU/mL (N=2,826) |
≥2000, <20000 IU/mL (N=1,665) |
≥20000 IU/mL (N=2,751) |
|---|---|---|---|---|---|
| Sex | |||||
| Male | 8,722 (69.6%) | 3,604 (68.2%) | 1,884 (66.7%) | 1,162 (69.8%) | 2,072 (75.3%) |
| Female | 3,805 (30.4%) | 1,681 (31.8%) | 942 (33.3%) | 503 (30.2%) | 679 (24.7%) |
| HBsAg | |||||
| ≥200 (IU/mL) | 6,853 (60.6%) | 2,076 (44.1%) | 1,477 (56.4%) | 1,095 (72.2%) | 2,205 (89.6%) |
| <200 (IU/mL) | 4,454 (39.4%) | 2,635 (55.9%) | 1,140 (43.6%) | 422 (27.8%) | 257 (10.4%) |
| HBeAg | |||||
| Positive | 1,633 (13.0%) | 285 (5.4%) | 151 (5.3%) | 160 (9.6%) | 1,037 (37.7%) |
| Negative | 10,889 (87.0%) | 5,000 (94.6%) | 2,674 (94.7%) | 1,503 (90.4%) | 1,712 (62.3%) |
| HCVAb | |||||
| Positive | 177 (1.6%) | 93 (2.0%) | 41 (1.6%) | 19 (1.2%) | 24 (1.0%) |
| Negative | 11,168 (98.4%) | 4,619 (98.0%) | 2,534 (98.4%) | 1,517 (98.8%) | 2,498 (99.0%) |
| Total diabetes | |||||
| Yes | 2,144 (17.1%) | 906 (17.1%) | 482 (17.1%) | 238 (14.3%) | 518 (18.8%) |
| No | 10,383 (82.9%) | 4,379 (82.9%) | 2,344 (82.9%) | 1,427 (85.7%) | 2,233 (81.2%) |
| FPG | |||||
| ≥7mmol/L | 1,383 (11.0%) | 558 (10.6%) | 301 (10.7%) | 163 (9.8%) | 361 (13.1%) |
| <7mmol/L | 11,144 (89.0%) | 4,727 (89.4%) | 2,525 (89.3%) | 1,502 (90.2%) | 2,390 (86.9%) |
| HbA1c | |||||
| ≥6.5% | 503 (25.4%) | 199 (23.5%) | 116 (23.2%) | 65 (24.4%) | 123 (33.7%) |
| <6.5% | 1,474 (74.6%) | 648 (76.5%) | 383 (76.8%) | 201 (75.6%) | 242 (66.3%) |
| Mean Age (Years) | 53.2 (12.5) | 53.4 (12.5) | 53.8 (12.1) | 53.5 (11.9) | 51.9 (13.1) |
| FPG (mmol/L) | 4.98 (4.50-5.70) | 5.00 (4.53-5.72) | 4.99 (4.50-5.64) | 4.96 (4.50-5.64) | 4.89 (4.40-5.70) |
| HbA1c (%) | 5.7 (5.3-6.5) | 5.7 (5.3-6.4) | 5.7 (5.3-6.3) | 5.7 (5.3-6.4) | 5.9 (5.3-6.9) |
| White blood cell (x109/L) | 5.38 (4.11-6.97) | 5.35 (4.06-6.94) | 5.54 (4.27-7.08) | 5.48 (4.25-7.00) | 5.18 (3.98-6.86) |
| Red blood cell (x1012/L) | 4.14 (3.64-4.58) | 4.13 (3.60-4.59) | 4.18 (3.73-4.59) | 4.18 (3.71-4.61) | 4.10 (3.57-4.53) |
| Hemoglobin (g/L) | 127.0 (111.0-141.0) | 126.0 (108.0-141.0) | 127.0 (113.0-141.0) | 129.0 (114.0-143.0) | 127.0 (111.0-141.0) |
| Platelet (x109/L) | 167.0 (111.0-219.0) | 169.0 (110.0-224.0) | 176.0 (127.0-228.8) | 171.0 (119.0-219.3) | 150.0 (96.0-201.0) |
| APTT (s) | 37.6 (34.9-40.8) | 37.5 (34.7-40.6) | 37.1 (34.6-40.4) | 37.3 (35.1-40.4) | 38.2 (35.4-41.6) |
| Prothrombin Time (s) | 13.7 (13.0-14.7) | 13.5 (12.9-14.5) | 13.5 (12.9-14.4) | 13.6 (13.0-14.6) | 14.1 (13.2-15.4) |
| INR | 1.06 (0.99-1.17) | 1.05 (0.98-1.15) | 1.05 (0.99-1.14) | 1.06 (1.00-1.16) | 1.11 (1.02-1.24) |
| Fibrinogen (g/L) | 2.99 (2.41-3.93) | 3.06 (2.46-4.04) | 3.05 (2.50-3.94) | 2.93 (2.38-3.81) | 2.86 (2.25-3.77) |
| Thrombin Time (s) | 17.9 (16.8-19.2) | 17.7 (16.7-18.9) | 17.8 (16.7-19.0) | 17.9 (16.8-19.2) | 18.5 (17.3-20.0) |
| Total bilirubin (μmol/L) | 13.9 (9.9-20.6) | 13.2 (9.4-19.2) | 13.5 (9.8-19.2) | 13.8 (10.1-20.6) | 16.1 (11.1-25.8) |
| ALT (IU/L) | 28.0 (18.0-50.0) | 24.0 (16.0-39.0) | 25.0 (16.0-42.0) | 29.0 (19.0-50.0) | 46.0 (29.0-92.0) |
| AST (IU/L) | 28.0 (20.0-51.0) | 25.0 (19.0-38.0) | 25.0 (19.0-42.0) | 28.0 (21.0-50.0) | 47.0 (29.0-94.0) |
| ALP (IU/L) | 81.0 (63.0-113.0) | 78.0 (62.0-105.0) | 77.0 (61.0-107.0) | 80.0 (62.0-111.0) | 94.0 (70.0-132.0) |
| GGT (IU/L) | 30.0 (17.0-75.0) | 27.0 (16.0-57.0) | 26.0 (16.0-62.0) | 30.0 (16.0-73.0) | 51.0 (24.0-120.0) |
| Total protein (g/L) | 64.9 (60.0-70.0) | 65.1 (60.0-70.1) | 65.4 (60.9-70.2) | 64.9 (60.4-69.9) | 64.0 (58.8-69.1) |
| Albumin (g/L) | 38.6 (34.1-42.2) | 39.0 (34.8-42.7) | 39.4 (35.2-42.6) | 39.0 (34.8-42.4) | 36.4 (31.7-40.6) |
| Triglycerides (mmol/L) | 1.00 (0.74-1.43) | 1.02 (0.74-1.49) | 1.03 (0.76-1.48) | 0.98 (0.75-1.38) | 0.95 (0.72-1.29) |
| Total Cholesterol (mmol/L) | 3.92 (3.27-4.65) | 3.88 (3.25-4.63) | 4.04 (3.40-4.72) | 3.99 (3.37-4.68) | 3.80 (3.12-4.61) |
| HDL Cholesterol (mmol/L) | 1.09 (0.86-1.36) | 1.09 (0.86-1.34) | 1.12 (0.89-1.40) | 1.12 (0.88-1.39) | 1.05 (0.80-1.32) |
| LDL Cholesterol (mmol/L) | 2.28 (1.75-2.87) | 2.25 (1.77-2.85) | 2.37 (1.82-2.96) | 2.35 (1.78-2.92) | 2.21 (1.64-2.79) |
ALP, Alkaline Phosphatase; ALT, Alanine Aminotransferase; APTT, Activated Partial Thromboplastin Time; AST, Aspartate Aminotransferase; DNA, Deoxyribonucleic Acid; FPG, Fasting Plasma Glucose; GGT, Gamma-glutamyl Transferase; HbA1c, Glycated Hemoglobin; HBeAg, Hepatitis B e Antigen; HBsAg, Hepatitis B Surface Antigen; HBV, Hepatitis B Virus; HCV, Hepatitis C Virus. HDL, High-density Lipoprotein; INR, International Normalized Ratio; IQR, Interquartile Range; LDL, Low-density Lipoprotein; SD, Standard Deviation.
Data are n (%), mean (SD) or median (IQR).