Table 2.
Transcription factors upstream of Tex-related hub genes.
| Key TF | Description | P value | Q value | List of overlapped genes |
|---|---|---|---|---|
| ILF3 | Interleukin enhancer binding factor 3, 90kDa | 1.24E-05 | 0.000136 | HLA-DRB1, HLA-DRA |
| RFXANK | Regulatory factor X-associated ankyrin-containing protein | 6.16E-05 | 0.000226 | HLA-DRA, HLA-DRB1 |
| RFXAP | Regulatory factor X-associated protein | 6.16E-05 | 0.000226 | HLA-DRB1, HLA-DRA |
| RFX5 | Regulatory factor X, 5 (influences HLA class II expression) | 8.96E-05 | 0.000246 | HLA-DRA, HLA-DRB1 |
| CIITA | Class II, major histocompatibility complex, transactivator | 0.000271 | 0.000595 | HLA-DRB1, HLA-DRA |
| RELA | V-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.00159 | 0.00254 | TNF, PTPN6,AKT1 |
| NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.00162 | 0.00254 | PTPN6, AKT1, TNF |
| AR | Androgen receptor | 0.00242 | 0.00333 | CDC6, AKT1 |
| E2F1 | E2F transcription factor 1 | 0.00495 | 0.00605 | TNF, CDC6 |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | 0.00554 | 0.00608 | PTPN6, AKT1 |
| JUN | Jun proto-oncogene | 0.00608 | 0.00608 | RUNX2, TNF |