TABLE 10.
Effects of PSPL extract on biochemistry analysis in the subacute toxicity studies. Values are expressed as means ± SEM.
| Groups for the subacute toxicity study a | Satellite group for subacute toxicity study b | ||||||
|---|---|---|---|---|---|---|---|
| SC | ST 50 | ST 250 | ST 500 | ST 1000 | SSC | SST 1000 | |
| Renal function test | |||||||
| Sodium (mmol/L) | 144.50 ± 0.56 | 144.50 ± 1.95 | 146.00 ± 1.03 | 146.00 ± 0.82 | 143.00 ± 0.49 | 144.80 ± 0.20 | 145.17 ± 0.79 |
| Potassium (mmol/L) | 8.43 ± 1.74 | 10.48 ± 0.29 | 9.65 ± 0.79 | 10.10 ± 0.49 | 10.64 ± 0.36 | 11.00 ± 0.00 | 10.78 ± 0.22 |
| Chloride (mmol/L) | 98.50 ± 0.56 | 100.00 ± 0.82 | 97.25 ± 0.48 | 99.00 ± 0.77 | 98.40 ± 0.93 | 97.00 ± 0.71 | 100.67 ± 1.43 |
| Urea (mmol/L) | 7.18 ± 0.33 | 7.70 ± 0.60 | 8.70 ± 0.89 | 8.55 ± 0.52 | 6.88 ± 0.24 | 8.60 ± 0.15 | 7.73 ± 0.61 |
| Creatinine (mmol/L) | 57.50 ± 3.43 | 55.33 ± 2.87 | 60.25 ± 1.60 | 53.33 ± 1.80 | 52.40 ± 2.58 | 54.60 ± 2.25 | 51.33 ± 4.62 |
| Liver function test | |||||||
| Total protein (g/L) | 70.00 ± 0.82 | 71.17 ± 0.98 | 76.25 ± 0.48 | 70.17 ± 1.17 | 69.40 ± 0.93 | 74.00 ± 0.55 | 75.33 ± 1.28 |
| Albumin (g/L) | 38.83 ± 0.87 | 40.00 ± 0.68 | 42.50 ± 0.50 | 39.83 ± 1.08 | 36.40 ± 0.40 | 40.60 ± 0.51 | 41.83 ± 0.48 |
| Globulin (g/L) | 31.17 ± 1.10 | 31.17 ± 1.01 | 33.75 ± 0.25 | 30.33 ± 0.88 | 33.00 ± 1.00 | 33.40 ± 0.51 | 33.50 ± 0.96 |
| Albumin–globulin ratio | 1.26 ± 0.06 | 1.29 ± 0.05 | 1.26 ± 0.02 | 1.32 ± 0.06 | 1.09 ± 0.04 | 1.22 ± 0.03 | 1.25 ± 0.03 |
| ALP (U/L) | 225.00 ± 17.25 | 211.17 ± 13.96 | 254.67 ± 18.08 | 212.67 ± 14.99 | 214.60 ± 27.78 | 254.20 ± 32.93 | 186.83 ± 18.37 |
| AST (U/L) | 118.83 ± 14.43 | 149.33 ± 17.80 | 115.75 ± 14.52 | 126.00 ± 6.79 | 128.60 ± 14.02 | 156.00 ± 11.97 | 115.83 ± 12.78 |
| ALT (U/L) | 71.50 ± 9.83 | 77.17 ± 6.46 | 86.25 ± 11.60 | 86.17 ± 8.11 | 86.80 ± 10.17 | 108.40 ± 11.63 | 77.33 ± 9.02 |
| GGT (U/L) | 0.67 ± 0.21 | 1.17 ± 0.31 | 1.25 ± 0.25 | 1.00 ± 0.00 | 1.20 ± 0.20 | 1.00 ± 0.00 | 1.00 ± 0.00 |
| Total bilirubin (µmol/L) | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 |
a
Groups for the subacute toxicity study.
b
Satellite groups for the subacute toxicity study.
ALP, alkaline phosphatase; AST, aspartate transaminase; ALT, alanine transaminase; GGT, gamma-glutamyl transferase; SC, subacute control; ST 50, 50 mg/kg of PSPL; ST 250, 250 mg/kg of PSPL; ST 500, 500 mg/kg of PSPL; ST 1000, 1,000 mg/kg of PSPL, SSC, subacute satellite control group; SST, subacute satellite group.