TABLE 8.
Relative organ weights of rats treated with PSPL extract in the subacute toxicity study. Values are expressed as means ± SEM.
| Organs | Groups for the subacute toxicity study a | Satellite group for the subacute toxicity study b | ||||||
|---|---|---|---|---|---|---|---|---|
| SC | ST 50 | ST 250 | ST 500 | ST 1000 | SSC | SST 1000 | ||
| Relative organ weight (g) | ||||||||
| Heart | 1.26 ± 0.07 | 1.17 ± 0.11 | 1.14 ± 0.03 | 1.31 ± 0.05 | 1.22 ± 0.06 | 1.02 ± 0.07 | 1.17 ± 0.04 | |
| Liver | 11.60 ± 0.67 | 11.95 ± 0.53 | 12.41 ± 0.63 | 11.97 ± 0.90 | 10.51 ± 0.80 | 11.73 ± 0.85 | 11.37 ± 0.62 | |
| Lungs | 2.21 ± 0.24 | 1.98 ± 0.12 | 1.92 ± 0.10 | 2.15 ± 0.26 | 2.15 ± 0.14 | 1.99 ± 0.12 | 2.09 ± 0.14 | |
| Kidney | 2.58 ± 0.06 | 2.52 ± 0.12 | 2.56 ± 0.12 | 2.48 ± 0.17 | 2.55 ± 0.09 | 2.43 ± 0.16 | 2.54 ± 0.10 | |
| Retina | 0.40 ± 1.74 | 0.35 ± 0.04 | 0.31 ± 0.03 | 0.29 ± 0.04 | 0.34 ± 0.03 | 0.53 ± 0.20 | 0.37 ± 0.05 | |
| RpWAT | 5.45 ± 0.52 | 3.61 ± 0.82 | 3.48 ± 0.41 | 3.57 ± 0.59 | 3.46 ± 0.69 | 3.12 ± 0.49 | 3.65 ± 0.52 | |
| Visceral fat | 2.33 ± 0.15 | 1.26 ± 0.37 | 1.86 ± 0.20 | 1.70 ± 0.37 | 1.79 ± 0.36 | 1.55 ± 0.20 | 1.41 ± 0.19 | |
| Gonadal fat | 3.70 ± 0.57 | 3.72 ± 0.67 | 2.95 ± 0.61 | 3.46 ± 0.51 | 3.43 ± 0.20 | 2.90 ± 0.31 | 4.00 ± 0.42 | |
| Pancreas | 1.10 ± 0.12 | 1.22 ± 0.09 | 0.99 ± 0.08 | 0.98 ± 0.09 | 1.15 ± 0.09 | 1.27 ± 0.41 | 0.91 ± 0.08 | |
| Spleen | 0.81 ± 0.05 | 0.75 ± 0.10 | 0.65 ± 0.03 | 0.67 ± 0.06 | 0.75 ± 0.05 | 0.69 ± 0.07 | 0.66 ± 0.04 | |
| Percentage per body weight (%) | ||||||||
| Heart | 0.35 ± 0.01 | 0.33 ± 0.03 | 0.33 ± 0.01 | 0.39 ± 0.02 | 0.37 ± 0.02 | 0.31 ± 0.02 | 0.32 ± 0.01 | |
| Liver | 3.26 ± 0.17 | 3.40 ± 0.09 | 3.61 ± 0.22 | 3.49 ± 0.17 | 3.15 ± 0.15 | 3.23 ± 0.11 | 3.10 ± 0.17 | |
| Lungs | 0.62 ± 0.07 | 0.57 ± 0.04 | 0.56 ± 0.02 | 0.63 ± 0.07 | 0.65 ± 0.05 | 0.57 ± 0.05 | 0.57 ± 0.03 | |
| Kidney | 0.73 ± 0.04 | 0.72 ± 0.02 | 0.74 ± 0.03 | 0.73 ± 0.04 | 0.77 ± 0.02 | 0.68 ± 0.02 | 0.69 ± 0.02 | |
| Retina | 0.11 ± 0.01 | 0.10 ± 0.01 | 0.09 ± 0.01 | 0.09 ± 0.01 | 0.10 ± 0.01 | 0.09 ± 0.01 | 0.10 ± 0.01 | |
| RpWAT | 1.57 ± 0.19 | 1.00 ± 0.22 | 1.01 ± 0.11 | 1.03 ± 0.14 | 1.04 ± 0.21 | 0.93 ± 0.20 | 0.98 ± 0.13 | |
| Visceral fat | 0.66 ± 0.06 | 0.36 ± 0.10 | 0.54 ± 0.05 | 0.49 ± 0.10 | 0.53 ± 0.10 | 0.43 ± 0.07 | 0.39 ± 0.06 | |
| Gonadal fat | 1.07 ± 0.17 | 1.04 ± 0.16 | 0.88 ± 0.1 | 1.00 ± 0.12 | 1.04 ± 0.06 | 0.81 ± 0.09 | 1.08 ± 0.10 | |
| Pancreas | 1.07 ± 0.17 | 1.04 ± 0.16 | 0.88 ± 0.18 | 1.00 ± 0.12 | 1.04 ± 0.06 | 0.26 ± 0.03 | 0.25 ± 0.03 | |
| Spleen | 0.23 ± 0.01 | 0.21 ± 0.03 | 0.19 ± 0.01 | 0.20 ± 0.02 | 0.23 ± 0.01 | 0.18 ± 0.00 | 0.18 ± 0.01 | |
a
Groups for the subacute toxicity study.
b
Satellite groups for the subacute toxicity study.
RpWAT, retroperitoneal white adipose tissue; SC, subacute control; ST 50, 50 mg/kg of PSPL; ST 250, 250 mg/kg of PSPL; ST 500, 500 mg/kg of PSPL; ST 1000, 1,000 mg/kg of PSPL, SSC, subacute satellite control group; SST, subacute satellite group.