TABLE 9.
Hematological effects of different treatment doses of PSPL extract on male Sprague–Dawley rats in the subacute toxicity study. Values are expressed as means ± SEM.
| Groups for the subacute toxicity study 9 | Satellite group for the subacute toxicity study b | ||||||
|---|---|---|---|---|---|---|---|
| SC | ST 50 | ST 250 | ST 500 | ST 1000 | SSC | SST 1000 | |
| Hb (g/dL) | 15.50 ± 0.55 | 15.75 ± 0.36 | 16.48 ± 0.42 | 15.60 ± 0.35 | 15.33 ± 0.29 | 16.27 ± 0.49 | 17.08 ± 0.61 |
| RBC (x10^12/L) | 8.91 ± 0.33 | 9.06 ± 0.22 | 9.54 ± 0.30 | 8.89 ± 0.13 | 8.97 ± 0.18 | 9.59 ± 028 | 9.92 ± 0.35 |
| RDW (%) | 17.45 ± 0.53 | 17.57 ± 0.37 | 17.43 ± 0.85 | 17.12 ± 0.33 | 17.43 ± 0.21 | 18.02 ± 0.35 | 18.68 ± 0.47 |
| PCV (%) | 55.67 ± 1.96 | 56.00 ± 1.48 | 58.33 ± 1.54 | 54.50 ± 1.50 | 52.50 ± 1.02 | 58.00 ± 1.65 | 58.50 ± 1.95 |
| MCV (fL) | 62.33 ± 0.84 | 61.83 ± 1.01 | 61.50 ± 0.10 | 61.17 ± 1.25 | 58.50 ± 0.72 | 60.50 ± 0.62 | 58.83 ± 0.54 |
| MCH (pg) | 17.67 ± 0.21 | 17.33 ± 0.21 | 17.50 ± 0.22 | 17.50 ± 0.22 | 17.17 ± 0.17 | 17.00 ± 0.26 | 17.17 ± 0.31 |
| MCHC (g/dL) | 28.00 ± 0.26 | 28.33 ± 0.32 | 28.17 ± 0.17 | 28.50 ± 0.29 | 29.00 ± 0.00 | 28.33 ± 0.33 | 29.33 ± 0.33 |
| WBC (x10^9/L) | 19.62 ± 3.16 | 19.30 ± 2.24 | 17.03 ± 2.10 | 20.57 ± 1.31 | 19.12 ± 0.89 | 19.78 ± 1.43 | 20.62 ± 1.74 |
| Neutrophils (x10^9/L) | 3.93 ± 1.06 | 3.65 ± 0.24 | 3.55 ± 0.46 | 4.87 ± 0.39 | 3.38 ± 0.65 | 3.58 ± 0.36 | 2.67 ± 0.27 |
| Lymphocytes (x10^9/L) | 13.52 ± 1.85 | 14.65 ± 1.97 | 12.28 ± 1.77 | 34.22 ± 19.59 | 14.83 ± 0.94 | 14.70 ± 1.11 | 16.73 ± 1.56 |
| Monocytes (x10^9/L) | 1.88 ± 1.04 | 0.72 ± 0.15 | 0.95 ± 0.35 | 0.97 ± 0.13 | 0.62 ± 0.08 | 1.15 ± 0.44 | 0.93 ± 0.24 |
| Eosinophils (x10^9/L) | 0.17 ± 0.04 | 0.19 ± 0.02 | 0.15 ± 0.03 | 0.20 ± 0.03 | 0.23 ± 0.02 | 0.23 ± 0.04 | 0.18 ± 0.04 |
| Basophils (x10^9/L) | 0.10 ± 0.03 | 0.07 ± 0.02 | 0.08 ± 0.02 | 0.10 ± 0.00 | 0.10 ± 0.00 | 0.10 ± 0.00 | 0.10 ± 0.00 |
| Platelet (x10^9/L) | 1,053.50 ± 45.11 | 1,231.67 ± 73.97 | 1,205.50 ± 45.70 | 1,247.00 ± 96.80 | 1,158.50 ± 64.27 | 1,215.67 ± 98.12 | 1,265.83 ± 80.51 |
a
Group for the subacute toxicity study.
b
Satellite groups for the subacute toxicity study.
Hb, hemoglobin; RBC, red blood cell; RDW, red cell distribution width; PCV, packed cell volume; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; WBC, white blood cell; SC, subacute control; ST 50, 50 mg/kg of PSPL; ST 250, 250 mg/kg of PSPL; ST 500, 500 mg/kg of PSPL; ST 1,000, 1,000 mg/kg of PSPL, SSC, subacute satellite control group; SST, subacute satellite group.