Figure 8.
Construction of the upstream regulatory network of hub genes. Base on the ENCORI database, we predicted miRNAs that simultaneously target COL1A1 (A), TGFBI (B), MMP1 (C), COL4A1 (D), NID2 (E), CXCL1 (F) and their ceRNA molecules. Then, the list of these candidate hub genes, lncRNAs and miRNAs were imported into Cytoscape software to construct the ceRNA network of hub genes. The red color represents hub genes, the pink color represents miRNAs, and the fruit green color represents lncRNAs. The connecting lines between different genes represent the predicted interactions.