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. 2023 Apr 12;16:1523–1532. doi: 10.2147/JIR.S403819

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© 2023 Shi et al.

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The process of PANoptosis and the formation of PANoptosome. After stimulated, ZBP1, RIP1, RIP3, caspase-1, ASC, NLRP3, FADD and caspase-8 form PANoptosome, mediating PANoptosis. Caspase-6 is a factor regulating the interaction between RIP3 and ZBP1.