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. 2023 Apr 3;91:104549. doi: 10.1016/j.ebiom.2023.104549

Fig. 6.

Fig. 6

TLR agonist induces an increase in HIV-specific memory CD4+ T-cell response. (a) Sum of IL2, TNFα, IFNγ, IL17a and CD107a intracellular memory CD4 T-cell production in response to HIV (Gag)-specific peptide pool minus the condition without Gag-stimulation. (b–d) Single cytokine intracellular memory CD4 T-cell production in response to HIV (Gag)-specific peptide pool minus the condition without Gag-stimulation. (e) Correlations between cytokine production of previously stimulated pDCs with GS9620 and single cytokine intracellular memory CD4 T-cell production in response to HIV (Gag)-specific peptide pool after co-culture minus the condition without Gag-stimulation. (f) Correlations between fold change expression of BST2, SAMHD1, APOBEC3G and TRIM5α of previously stimulated pDCs with respect to the unstimulated condition and single cytokine intracellular CD4 memory T-cell production in response to HIV (Gag)-specific peptide pool after co-culture minus the condition without Gag-stimulation. Friedman test including Dunn's multiple comparisons test correction was applied. Spearman p correlation coefficient test was used. Statistically significant values are shown as: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. VIR, Viremic; INR, Immune Non Responders; IR, Immune Responders and EC, HIV Elite Controllers.