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. 2023 Apr 3;91:104549. doi: 10.1016/j.ebiom.2023.104549

Fig. 7.

Fig. 7

TLR agonist induces an increase in HIV-specific CD8 memory response. (a) Sum of IL2, TNFα, IFNγ, Perforin and CD107a production in response to HIV (Gag)-specific peptide pool minus the condition without Gag-stimulation. (b–d) Single cytokine intracellular memory CD8 T-cell production in response to HIV (Gag)-specific peptide pool minus the condition without Gag-stimulation. (e) HIV-specific CD8 T-cell polyfunctionality pie charts. Permutation test, following the Spice version 6 software was used to assess differences between pie charts. (f) Positive correlations between the pDCs fold change of TNFα, IFNα, IRF3 and IRF7 expression after GS9620 stimulation with respect to the unstimulated condition and the HIV-specific memory CD8 T-cell response. Friedman test including Dunn's multiple comparisons test correction was applied. Spearman p correlation coefficient test was used. Statistically significant values are shown as: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. VIR, Viremic; INR, Immune Non Responders; IR, Immune Responders and EC, HIV Elite Controllers.