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Proposed mechanisms
STING increases NLPR3 and NLRP3 inflammasome-mediated hepatocyte pyroptosis during liver injury via epigenetic regulation of the IRF3/WDR5/DOT1L transcription activator complex. STING-NLRP3 pathway leads to liver fibrosis by increasing hepatocyte pyroptosis, hepatic inflammation, and metabolic reprogramming.
