Table 1.
Clinical and biochemical characteristics of patient cohorts
| Cohort 2 | Cohort 3 | Cohort 4 | ||
|---|---|---|---|---|
| Obese | Lean | Obese | Obese | |
| Subjects | 43 | 6 | 6 | 6 |
| Gender (females) | 69.8% (30/43) | 50% (3/6) | 100% | 66.7% (4/6) |
| Age (years) | 40 (19‐65) | 72 (61‐84) | 44 (22‐61) | 44 (23‐55) |
| T2D | 9/43 | 0/6 | 1/6 | 0 |
| BMI (kg/m2) | 38.8 (33.1‐51.8) | 22.5 (18.3‐23.7) | 42.6 (35.1‐48.5) | 40.7 (36.9‐47.5) |
| Fasting glucose (mmol/L) | 5.6 (4.4‐11.4) | 6.7 (5.4‐10) | 4.9 (4.6‐6.8) | 5.5 (5.3‐6.1) |
| HbA1c (mmol/mol) | 36 (29‐95) | 38 (28‐67) | 36 (32‐49) | 36 (34‐39) |
| CRP (mg/L) | 5 (1‐16) | 1 (1‐30) | 2.5 (1‐21) | 4 (1‐20) |
| Insulin (mIU/L) | 18.3 (5.2‐63.5) | 16.3 (4.7‐30.7) | 16.8 (6.6‐32.4) | |
| HOMA‐IR | 4.7 (1.1‐18.3) | 3.5 (1‐9.3) | 4.0 (1.6‐7.9) | |
| C‐peptide (mmol/L) | 1.1 (0.3‐2.9) | 0.9 (0.4‐1.6) | ||
| Total cholesterol (mmol/L) | 4.6 (2.5‐8.3) | 4.1 (3.1‐7.0) | 1.0 (0.7‐1.7) | |
| LDL (mmol/L) | 3.1 (1.1‐6.1) | 2.5 (1.6‐4.8) | 2.5 (1.8‐4.3) | |
| HDL (mmol/L) | 1.1 (0.6‐2.0) | 1.1 (0.9‐1.8) | 1.3 (0.8‐1.6) | |
| TAG (mmol/L) | 1.6 (0.5‐6.9) | 1.2 (0.9‐1.5) | 1.4 (1‐0‐3.3) | |
Data are given as median (range). All circulating parameters are measured from fasting blood samples. F, females; T2D, type 2 diabetes; BMI, body mass index; CRP, C‐reactive protein; HOMA‐IR, homeostatic model assessment of insulin resistance index; LDL, low‐density lipoprotein cholesterol; HDL, high‐density lipoprotein cholesterol; TAG; triacylglycerol.