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. 2023 Mar 21;29(11):1669–1684. doi: 10.3748/wjg.v29.i11.1669

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Multiphasic computed tomography study for assessment of treatment response (after sorafenib). A-D: A 66-year-old female underwent conventional medical therapy (sorafenib) for an advanced hepatocellular carcinoma (HCC) lesion. Computed tomography images represented the complete response to the medical therapy, with no areas or nodular lesions suspected for HCC; E-H: During the follow-up, 2 years after completion of therapy, a nodular hypoattenuating lesion in the unenhanced phase (E) appeared in the VII hepatic segment. This lesion had similar features of primary HCC, with non-rim hyperenhancement during the arterial phase (F), wash-out during the portal venous phase (G) and delayed phase (H). This is an example of HCC recurrence after sorafenib.