TABLE 2.
Demographic information of the study cohort
| Number of pregnant women | 372 |
|---|---|
| Mean whole blood volume (min–max) | 17.57 ml (9.5–20.5 ml) |
| Mean gestational age (min–max) | 12.20 weeks (10–20 weeks) |
| Fetal gender | 195 F, 181 M, 7 not known |
| Number of fetuses | 361 singletons, 11 twins |
| Mean maternal age (min–max) | 35.30 years (20–47 years) |
| Mean maternal BMI (min–max) | 22.79 kg/m2 (14.7–40.0 kg/m2) |
| Referral reason | |
| FCT | 36.83% (n = 137) |
| cfDNA test | 12.10% (n = 45) |
| CVS | 46.51% (n = 173) |
| AFS | 4.57% (n = 17) |
| Indications for CVS and AFS | |
| Advanced maternal age | 21.11% (n = 42) |
| Abnormal ultrasound findings | 5.26% (n = 10) |
| Positive FCT | 53.68% (n = 102) |
| Positive cfDNA | 4.21% (n = 8) |
| Other a | 14.74% (n = 28) |
| Gestational age (range) | |
| 10–11 weeks | 31.72% (n = 118) |
| 12–14 weeks | 63.71% (n = 237) |
| 15–20 weeks | 4.57% (n = 17) |
Abbreviations: AFS, Amniocentesis; BMI, Body Mass Index; cfDNA, high‐risk cell‐free DNA; CVS, Chorionic Villus Sampling; FCT, high‐risk First trimester Combined Test.
a
Includes: Parent carrier of a chromosomal abnormality, prior affected pregnancy, and risk for monogenic disorders.