TABLE 2.

Number of LoF AXIN2 variant ^a carriers in patients suspected of genetic predisposition to CRC and controls.

Population	Nb of carriers	OR (95% CI)	p Value b
Patients c (n = 3322)	8 (0.24%)	11.39 (5.103–28.93)	<0.0001
Controls (non‐cancer, NFE) d (n = 59 095)	12 (0.020%)

^a LoF AXIN2 variants include stop‐gain, frameshift, canonical splice‐site, and start‐loss variants.

^b Frequencies between groups were compared using Fisher's exact test. Associated ORs were calculated for each group.

^c Only patients tested in consecutive series were considered (Figure 1).

^d Control population data were obtained from gnomAD v2.1 (non‐cancer, non‐Finnish European individuals).