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. 2022 Dec 16;13:1072651. doi: 10.3389/fphar.2022.1072651

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Copyright © 2022 Zhang, Wang, Li, Lei, Xiang, Ouyang, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Process and mechanism of DNA methylation. (A) The overall process of CpG methylation by DNMT. (B) Mechanism of DNA methylation in DNA (cytosine-5)-methyltransferase. (C) Crystal structure of human DNA methyltransferase 1 with AdoHcy (PBD code: 4WXX). The RFTS, CXXC, MTase, and BAH domains are colored in green, black, light blue, and yellow, respectively. SAH is colored in pink and residue C1226 is colored in gray.