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. 2022 Dec 23;42(2):340–366. doi: 10.1002/etc.5491

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Published 2022. This article is a U.S. Government work and is in the public domain in the USA. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Exposure activity ratios (EARs) from mixtures of pesticides and pesticide transformation products by site and across ToxCast assay gene targets (EAR_gene) for passive (left) and discrete water (right) samples collected in 15 Great Lakes tributaries, June–July 2016. Assays included had EAR_gene > 10^–3 in at least two sites for either method. Genes are ordered by median EAR_gene among all sites, endpoints, and methods. For one endpoint without a specific gene target, the gene name was replaced with the hormone induced by the ToxCast assay (i.e., estrone). The upper and lower edges are the 25th and 75th percentiles, and whiskers are drawn up to 1.5 times the interquartile range.