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Mutated MYD88 upregulates BTK and HCK. HCK is activated by IL‐6 through IL‐6 receptor/GP‐130 signaling triggered by autocrine and paracrine IL‐6 production from the surrounding bone marrow stroma. Activated HCK triggers BTK activation that enables downstream ERK, STAT5, and NFKB activation. IRAK4 and IRAK1 are also triggered by mutated MYD88 that promote NFKB activation. [Color figure can be viewed at wileyonlinelibrary.com]
