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. 2023 Feb 22;14(4):411–416. doi: 10.1021/acsmedchemlett.2c00461

Figure 1.

Figure 1

Syntheses of BODIPY-labeled fluorescent probes 1417. Reagents and conditions: (a) Cs2CO3, DMF, at 50 °C overnight, 34–47% (b) 2-(prop-2-yn-1-yloxy)ethan-1-ol, PPh3, DIAD, THF, from 0 °C to room temperature overnight, 35%. (c) CuSO4·5H2O, sodium ascorbate, THF: H2O (1:1, v/v), at 50 °C overnight, 73–81%. (d) LiOH, H2O: MeOH (1:1, v/v), at room temperature for 2 h, 65–81%.