Figure 4.

APOBEC3 does not drive NRAS, HRAS, or KIT genetic alterations in head/neck MMs. (A) NGS findings in primary sinonasal MMs (n = 10). (B) Type and nucleotide context of the most common pathogenic mutations discovered by NGS in primary sinonasal MMs. None of the NRAS, HRAS, or KIT base substitutions occurred in a 5′‐TCA‐3′ or 5′‐TCT‐3′ trinucleotide context, which represent the preferred DNA motifs for APOBEC3. [Color figure can be viewed at wileyonlinelibrary.com] [Color figure can be viewed at wileyonlinelibrary.com]