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. Author manuscript; available in PMC: 2023 Apr 17.
Published in final edited form as: Biomaterials. 2021 Apr 14;273:120819. doi: 10.1016/j.biomaterials.2021.120819

Fig. 1.

Fig. 1.

Synthesis, characterization, and adenosine loading/release profile of the nanocarriers. (a) Structure of the nanocarrier precursor polymer HA-MA-Aln. Chemical structure of (b) 3-APBA and (c) adenosine. (d) Schematic representation of alendronate conjugated nanocarrier (Aln-NC). (e) FTIR spectra of the NC and Aln-NC. (f) UV-visible absorbance spectra of the NC and Aln-NC. (g) Transmission electron microscope (TEM) images of the nanocarriers; size distribution profile of the nanocarriers is shown in the inset. Scale bar 200 nm. (h) Reaction scheme showing the reversible adenosine binding with PBA. (i) Cumulative release kinetics of adenosine from the nanocarriers in media containing 10% FBS.