FIGURE 2.

Affect‐associated mediodorsal (MD) thalamic functional connectivity (FC) network in chronic knee pain. (a) MD thalamic FC regression map (negative affect factor score) in chronic knee pain participants. All clusters displayed without cluster size threshold at Z > 2.3. (b) Moderation analysis showing that pain severity (ICOAP) moderates the association between MD thalamic FC and negative affect. (c) Illustration of slopes of the MD thalamus FC—negative affect relationship in pain severity subgroups with average [low/high] defined as mean ±1SD [<−1SD/> + 1SD] ICOAP. ICOAP = Intermittent and Constant Osteoarthritis Pain (questionnaire); mPFC = medial prefrontal cortex