Table 1.
Demographic and permeability characteristics overall and by diagnostic category.
| Characteristics | N | Total | AD | LA | MX | VCID | |
|---|---|---|---|---|---|---|---|
| (N = 39) | (N = 25) | (N = 17) | (N = 55) | p-value | |||
| Age | 136 | 68 [62; 75] | 70 [66; 76] | 63 [55; 68] | 76 [74; 79] | 67 [61; 71.5] | <0.0005 |
| Sex | 136 | 0.063 | |||||
| Female | 66 (48.5%) | 17 (43.6%) | 18 (72.0%) | 6 (35.3%) | 25 (45.5%) | ||
| Male | 70 (51.5%) | 22 (56.4%) | 7 (28.0%) | 11 (64.7%) | 30 (54.5%) | ||
| Years of education | 101 | 16 [14; 18] | 16 [14; 18] | 16 [12.5; 18] | 15 [13; 18] | 16 [13; 18] | 0.575 |
| Albumin Index | 131 | 6.40 [4.85; 7.95] | 6.69 [5.21; 7.60] | 4.85 [3.90; 6.02] | 7.00 [4.60; 9.40] | 7.05 [5.67; 8.50] | 0.001 |
| MRI WM Permeability | 67 | 4.15 [1.13; 10.51] | 1.33 [0.44; 2.23] | 2.91 [1.13; 5.36] | 10.92 [7.78; 19.88] | 13.27 [5.92; 18.39] | <0.0005 |
Table values: Median [Q1; Q3] for numeric values and n (%) for categorical values. IQR bounds [Q1, Q3] are 25th and 75th percentiles. AD: Alzheimer's disease; LA: leukoaraiosis; MX: mixed dementia; vascular cognitive impairment and dementia: vascular cognitive impairment and dementia.
P-values reported from the Kruskal-Wallis test for continuous data, and from the chi-square test with continuity correction for categorical data.