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. 2023 Jan 12;43(5):694–711. doi: 10.1177/0271678X221135419

Figure 3.

Figure 3.

Enriched environment (EE) mitigates depression-like behaviors in mice after ICH. (a and b) Mice in the ICH + EE group exhibited less immobility time in the forced swim test (FST, a) and the tail suspension test (TST, b) on day 28 than ICH mice housed in a standard environment (SE). n = 8 mice/group. F = 7.47, 5.28, respectively; *p < 0.05 vs. sham group; #p < 0.05 vs. ICH + SE group (one-way ANOVA followed by Bonferroni’s post hoc test). (c) Mice in the ICH + EE group consumed more sucrose-sweetened water in the sucrose preference test than ICH mice in the standard environment on day 28. n = 10 mice/group. F = 21.85, *p < 0.05 vs. sham group; #p < 0.05 vs. ICH + SE group (one-way ANOVA followed by Bonferroni’s post hoc test). (d and e) In the light/dark transition test, the mice in the ICH + EE group spent more time in the light box (d) and less time in the dark box (e) than those in the ICH + SE group. n = 7–8. F = 8.954, 8.954, *p < 0.05 vs. sham group; ##p < 0.01 vs. ICH + SE group (one-way ANOVA followed by Bonferroni’s post hoc test) and (f) The number of entries in the lightbox was not statistically different between the ICH + SE and ICH + EE groups. n = 8 mice/group. F = 0.09439, Values are mean ± SD.