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. 2023 Mar 22;66(7):5041–5060. doi: 10.1021/acs.jmedchem.2c02132

Table 5. Structure–Activity Relationships of Compounds 15a–j.

graphic file with name jm2c02132_0020.jpg

compound	R²	DCAF1 K_D (nM)^a
15a	Me	NB
3b	Ph	16,400; 16,900
15b	2-Cl Ph	4000; 4100
15c	3-Cl Ph	11,100; 11,200
15d	4-Cl Ph	2890; 2890
15e	2-F Ph	3400; 3420
15f	3-F Ph	15,700; 15,700
15g	4-F Ph	13,280; 12,960
15h	4-OMe Ph	35,100; 34,700
15i	3-CN Ph	24,900; 26,500
15j	3-Cl, 4-F Ph	15,900; 15,800

^a

Experiments were performed in duplicate.