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. 2023 Mar 22;66(7):5041–5060. doi: 10.1021/acs.jmedchem.2c02132

Table 6. Structure–Activity Relationships of Compounds 26a–e.

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compound R1 R2 DCAF1 KD (nM)
26a (S) 3-Cl, 4-F Ph 2-F Ph 170; 180
26b (S) 3,4 di-Cl Ph 2-F Ph 200; 217
26c (S) 3-Cl Ph 2,4-F Ph 265; 282
26d (S) 3-Cl Ph 2-F, 4-Cl Ph 85 ± 10
26e (S) 3-Cl, 4-F Ph 2-F, 4-Cl Ph 38 ± 1.5