Fig. 2.

Clusters of type 2 diabetes loci. Top-weighted loci and traits in each of the ten clusters are represented in circular plots: (a) Beta cell 1, (b) Beta cell 2, (c) Proinsulin, (d) Lipoprotein A, (e) SHBG, (f) Obesity, (g) Lipodystrophy, (h) Liver/lipid, (i) ALP negative, (j) Hyper insulin secretion. The length of the bars shows the weights. Green bars represent top-weighted loci, red bars represent increased trait association, and blue bars represent decreased trait association with each cluster. A maximum of 35 elements (loci and traits) based on highest weights are displayed in each cluster. The blue outline indicates clusters associated with decreased fasting insulin levels, and the red outline indicates clusters associated with increased fasting insulin levels