Table 1.
Genes with rare variants implicated in AF
| Gene | Protein/Function |
|---|---|
| ABCC9 | ATP binding cassette subfamily C member 9; ion channel |
| C9orf3 | Chromosome 9 open reading frame 3; aminopeptidase-O |
| CAV1 | Caveolin1; plasma membrane scaffold |
| GATA4 | GATA binding protein 4; transcription factor: cardiac morphogenesis |
| GATA5 | GATA binding protein 5; transcription factor: cardiac morphogenesis |
| GATA6 | GATA binding protein 6; transcription factor: cardiac morphogenesis |
| GJA1 | Gap junction alpha-1 protein; gap junctions |
| GJA5 | Gap junction alpha-5 protein; gap junctions |
| HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; ion channel |
| JPH2 | Junctophilin-2; transverse-tubule and junctional membrane complex regulator |
| KCNA5 | Potassium voltage-gated channel, shaker-related subfamily, member 5; ion channel |
| KCND3 | Potassium voltage-gated channel subfamily D member 3; ion channel |
| KCNE1 | Potassium voltage-gated channel subfamily E regulatory subunit 1; ion channel |
| KCNE2 | Potassium voltage-gated channel subfamily E regulatory subunit 2; ion channel |
| KCNE5 | Potassium voltage-gated channel subfamily E regulatory subunit 5; ion channel |
| KCNH2 | Potassium voltage-gated channel subfamily H member 2; ion channel |
| KCNJ2 | Potassium voltage-gated channel subfamily J member 2; ion channel |
| KCNJ8 | Potassium voltage-gated channel subfamily D member 3; ion channel |
| KCNN3 | Potassium calcium-activated channel subfamily N member 3; ion channel |
| KCNQ1 | Potassium voltage-gated channel subfamily Q member 1; ion channel |
| MYH6 | Myosin heavy chain 6; sarcomere structure |
| MYL4 | Myosin light chain 4; sarcomere structure |
| NKX2–5 | NK2 homeobox 5; transcription factor: cardiac morphogenesis |
| NPPA | Natriuretic peptide precursor A; blood-volume control signal |
| NUP155 | Nucleoporin 155; nucleoporin structure |
| PITX2 | Paired like homeodomain 2; transcription factor: cardiac morphogenesis |
| RyR2 | Ryanodine receptor type-2; ion channel |
| SCN10A | Sodium voltage-gated channel alpha subunit 10; ion channel |
| SCN1B | Sodium voltage-gated channel beta subunit 1; ion channel |
| SCN2B | Sodium voltage-gated channel beta subunit 2; ion channel |
| SCN3B | Sodium voltage-gated channel beta subunit 3; ion channel |
| SCN4B | Sodium voltage-gated channel beta subunit 4; ion channel |
| SCN5A | Sodium voltage-gated alpha subunit 5; ion channel |
| SYNE2 | Spectin repeat-containing nuclear envelope protein 2; nuclear pore |
| ZFHX3 | Zinc finger homeobox 3; transcription factor: cardiac morphogenesis |