Table 2.
Genetic Disease Loci Associated with Common AF
| Nearest Gene(s) | Protein/Function |
|---|---|
| ANXA4–GMCL1 | Unknown-intergenic region |
| ASAH1–PCM1 | Unknown-intergenic region |
| C9orf3 | Chromosome 9 open reading frame 3; aminopeptidase |
| CAND2 | Cullin associated and neddylation dissociated; transcription factor: cardiac morphogenesis |
| CEP68 | Centrosomal protein 68; cytoskeleton |
| CUX2 | Cut like homeobox 2; transcription factor: cardiac morphogenesis |
| GJA1 | Gap junction alpha-1 protein; gap junctions |
| HAND2 | Heart and neural crest derivatives expressed 2; transcription factor: cardiac morphogenesis |
| HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; ion channel |
| KCND3 | Potassium voltage-gated channel subfamily D member 3; ion channel |
| KCNJ5 | Potassium voltage-gated channel subfamily J member 5; ion channel |
| KCNN2 | Potassium calcium-activated channel subfamily N member 2; ion channel |
| KCNN3 | Small conductance calcium-activated potassium (SK) channel 3; ion channel |
| KLHL3–WNT8A–FAM13B | Unknown-intergenic region |
| LINC01142-METTL11B | Unknown-intergenic region |
| METTL11B–KIFAP3 | Unknown-intergenic region |
| NEBL | Nebulette; sarcomere structure |
| NEURL1 | Neuralized E3 ubiquitin protein ligase 1; ubiquitin ligase |
| PITX2 | Paired like homeodomain 2; transcription factor:cardiac morphogenesis |
| PLEC | Plectin; cytoskeleton |
| PPF1A4 | Liprin-beta-1; protein tyrosine-phosphatase: axon guidance |
| PPRX1 | Paired related homoeobox 1; transcription factor: cardiac morphogenesis |
| SCN10A | Sodium voltage-gated channel alpha subunit 10; ion channel |
| SH3PXD2A | SH3 and PX domain-containing protein 2A; transcription factor: neural crest migration |
| SLC1A4-CEP68 | Unknown-intergenic region |
| SLC35F1–PLN | Unknown-intergenic region |
| SOX5 | SRY (sex determining region Y)-Box 5; transcription factor: cardiac morphogenesis |
| SYNE2 | Spectin repeat-containing nuclear envelope Protein 2; nuclear pore |
| SYNPO2L | Synaptopodin 2-like; cytoskeleton |
| TBX5 | T-box transcription factor 5; transcription factor: cardiac morphogenesis |
| TTN–TTN-AS1 | Unknown-intergenic region |
| ZFHX3 | Zinc finger homeobox 3; transcription factor: cardiac morphogenesis |