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Effect of simvastatin and L-OHP on Colon-26 tumor growth. a Treatment with 6 or 10 mg/kg L-OHP, and 10 mg/kg simvastatin for 3 weeks. b Treatment with 6 or 10 mg/kg L-OHP, and 50 mg/kg simvastatin for 3 weeks. Mean values and S.E.M. are shown. Statistical analysis was performed by ANOVA with Dunnett’s, and the difference was considered significant when P < 0.05. *P < 0.05; versus vehicle and #P < 0.05; versus 6 or 10 mg/kg oxaliplatin
