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. 2023 Feb 17;6(2):76–86. doi: 10.1093/abt/tbad002

Figure 5.

Figure 5

Neutralizing activity of nAbs against SARS-CoV-2 variants. (A) Neutralizing activities of nAbs A5–10, A8–1 and A34–2 against SARS-CoV-2 and variants. The ND50 of nAbs for each variant are shown in the table. ND50 values indicated the dose of each mAb for 50% neutralization of viral infection. (B) The structural insights into the immune evasion of A5–10 (left), A8–1 (middle) and A34–2 (right) by Omicron. The structures of A5–10, A8–1 and A34–2 in complex with WT-RBD (top) were superimposed with the structure of Omicron RBD (PDB code: 7WED) (bottom) with main mutations responsible for immune invasion marked out. Antibody A5–10, A8–1 and A34–2, WT-RBD and Omicron-RBD were colored in blue, purple, red, grey and cyan, respectively.