Table 1.
Reported cases of de novo IgAN following COVID-19 vaccination.
| Authors | Age | sex | PMH | Timeline of symptom onset | Type of Vaccine | Begin of symptoms | Laboratory features | treatment | outcome |
|---|---|---|---|---|---|---|---|---|---|
| Abdel-Qader et al. | 12 | M | N | <1 day after 1st dose | mRNA | GH;AKI; proteinuria | Scr:1.77mg/dl; proteinuria :1.7 g/l; RBC: 1920/ul; Renal biospy: IgAN | steroid | R |
| Mohamed et al. | 50 | M | seasonal allergy | 2 wk after 1st dose | mRNA | skin rash; proteinuria | UPCR:1.1 g/day; Renal biospy: IgAN Skin biopsy:IgA vasculitis; | steroid | R |
| Niel et al. | 13 | F | N | <1 day after 1st dose | mRNA | MH;asthenia; Muscle pain; fever | SCr: 3.57 mg/dl; proteinuria:3.9 g/l; Renal biospy: IgAN | steroid; HD | R |
| Okada et al. | 17 | F | AH | 4 days after 1st dose | mRNA | GH; proteinuria | SCr: 0.58 mg/dl; Renal biospy: IgAN | Conservative | CR |
| Fujita et al. | 40 | F | Occult blood | 9 days after 1st dose | mRNA | GH;Fever; Chills; shivering; back pain; general malaise; | SCr: 0.86 mg/dl; RBC: 100/HPF; ALB: >3 g/dl; Renal biospy: IgAN | TPE | CR |
| Yokote et al. | 36 | F | MH;RA Proteinuria; |
11 days after 1st dose | mRNA | GH | SCr: 0.9 mg/dl; UPCR: 15.6 g/g; RBC:>100/HPF;Renal biospy: IgAN | Steroid; immunosuppressive | R |
| 19 | M | MH | 18 h after 2nd dose | mRNA | GH | SCr: 0.97 mg/dl; RBC: 50–99/HPF; UPCR: 1.5 g/g; Renal biospy: IgAN | RASi | R | |
| Anderegg et al. | 39 | M | HTN | Immediate after 2nd dose | mRNA | Fever;GH flu-like symptoms | AKI;Renal biospy: IgAN | Steroid; immunosuppressive | R |
| 81 | M | N | after 2nd dose | mRNA | flu-like symptoms | Renal biospy: IgAN | Steroid; immunosuppressive plasmapheresis | R | |
| Klomjit et al. | 38 | M | NA | 2 wk after 2nd dose | mRNA | UK | Scr:1.6mg/dL; protein:0.32g/d; RBC:51-100/HPF; Renal biospy: IgAN | Conservative | NA |
| 44 | F | NA | 2 wk after 1st dose | mRNA | UK | Scr:2.5mg/dL; protein:14 g/d; RBC:21-30 /HPF; ALB:3.7g/dl; Renal biospy: IgAN | steroid | NR | |
| 66 | F | NA | 2 wk after 1st dose | mRNA | UK | Scr:1.5mg/dL; protein:1.2 g/d; RBC:51–100 /HPF; ALB:4.1g/dl; Renal biospy: IgAN | steroid | R | |
| 62 | M | NA | 6 wk after 1st dose | mRNA | UK | Scr:2.2mg/dL protein:0.9 g/d RBC:31–40 /HPF ALB:4.2g/dl Renal biospy: IgAN |
Conservative | R | |
| Lo et al. | 28 | F | MH | 3 h after 2nd dose | mRNA | GH | SCr: 72 μmol/L; UPCR: 320mg/mmol Renal biospy: IgAN |
Conservative | CR |
| Hanna et al. | 17 | M | N | <1 day after 2nd dose | mRNA | GH;AKI Proteinuria; |
SCr: 1.78 mg/dl; ALB: 3.8 g/dl; Renal biospy: IgAN | steroid | R |
| Nihei et al. | 28 | F | GH; proteinuria | 7 days after 2nd dose | mRNA | GH; fever | RBC: >100/HPF; UPCR: 0.13 g/g; Renal biospy: IgAN | Conservative | R |
| Abramson et al. | 30 | M | N | 1day after 2nd dose | mRNA | GH;proteinuria | SCr: 1.02 mg/dl; UPCR: 0.8 g/g; RBC: >30/HPF; Renal biospy: IgAN | RASi | PR |
| Tan et al. | 41 | F | GDM | 1day after 2nd dose | mRNA | Headache; GH generalized myalgia | RBC: >200; UPCR: 7.58g/g; SCr:541mmol/L; Renal biospy: IgAN | steroid; immunosuppressive | NA |
| 60 | F | N | 1day after 2nd dose | mRNA | GH | RBC: >200 ll; UPCR: 2.03 g/g; SCr:153mmol/L; Renal biospy: IgAN | steroid;TPE Immunosuppressive |
NA | |
| Park et al. | 50 | M | HTN | 1day after 2nd dose | mRNA | NA | SCr: 1.54 mg/dl; Renal biospy: IgAN | RASi | PR |
| 22 | F | N | 2day after 2nd dose | mRNA | NA | SCr: 0.8mg/dl; Renal biospy: IgAN | Conservative | R | |
| 39 | F | N | 2day after 2nd dose | mRNA | NA | SCr: 0.8 mg/dl; Renal biospy: IgAN | Conservative | R | |
| 67 | M | HTN | 1mo after 2nd dose | mRNA | NA | SCr: 2.90mg/dl; Renal biospy: IgAN | steroid; | PR | |
| Lim et al. | 42 | F | N | 1day after 2nd dose | mRNA | GH; proteinuria | SCr: 0.47 mg/dl; UTP :1.7 g/d; Renal biospy: IgAN | RASi | PR |
| Uchiyama et al. | 15 | M | MH | 1day after 2nd dose | mRNA | GH;Fever; myalgia | SCr: 0.97 mg/dl; numerous RBC; Renal biospy: IgAN | Conservative | R |
| 18 | M | MH | 2 day after 2nd dose | mRNA | GH | SCr: 0.82 mg/dl; numerous RBC; Renal biospy: IgAN | Conservative | R | |
| Kudose et al. | 50 | F | HTN; Obesity; APS | 2 day after 2nd dose | mRNA | GH;fever generalized body aches | SCr: 1.7 mg/dl; UPCR: 2 g/g, RBC: >50/HPF Renal biospy: IgAN | Conservative | R |
| 19 | M | MH | 2 day after 2nd dose | mRNA | GH | SCr: 1.2 mg/dl; numerous RBC Renal biospy: IgAN |
Conservative | R | |
| Horino et al. | 17 | M | MH | 2 day after 2nd dose | mRNA | fever;GH headache | SCr: 0.70 mg/dl; RBC: >100/HPF; Renal biospy: IgAN | Tonsillectomy; steroid | PR |
| Srinivasan et al. | 35 | M | Nephrolithiasis UC | 2 day after 2nd dose | mRNA | GH;foamy urine | SCr: 1.3 mg/dl; UPCR: 0.656 g/g Renal biospy: IgAN |
immunosuppressive | PR |
| Morisawa et al. | 16 | M | AH | 2 day after 2nd dose | mRNA | Fever; GH | SCr: 1.1 mg/dl; UPCR:0.28 g/g Renal biospy: IgAN |
Steroid; immunosuppressive | R |
| 13 | F | AH | 2 day after 2nd dose | mRNA | Fever; GH | SCr: 0.54 mg/dl; UPCR: 1.99 g/g; Renal biospy: IgAN | Conservation | R | |
| Alonso et al. | 30 | M | MPGN type 1; CKD;KT | 34 day after 2nd dose | mRNA | NA | SCr: 1.65 mg/dl; hematuria: 150/ml; Renal biospy: IgAN | Steroid | NR |
| Mokos et al. | 73 | M | HTN; KT; AAN | 5 wk after 2nd dose | Viral vector | lower leg edema | SCr: 1.67 mg/dl; UTP: 1.4 g/d, RBC: 3–5/HPF Renal biospy: IgAN | RASi | NR |
| Fenoglio et al. | 74 | M | UK | 6 wk after 1st dose | Viral vector | RF;NS | Renal biospy: IgAN | Steroid; hemodialysis | NA |
| 79 | M | UK | 61 days after 1st dose | Viral vector | RF;NS | Renal biospy: IgAN | Steroid; immunosuppressive | NA | |
| Chen et al. | 55 | M | N | <1day after 1st dose | mRNA | AKI;general malaise abnormal liver function; nausea;vomiting | Scr: 1.94 mg/dl; UTP:11.57 g; Renal biospy: IgAN | Conservation | NR |
| Ran et al. | 58 | M | N | 2 days after 1st dose | inactivated | GH;dizziness; generalized body aches; lower limb edema | Scr: 7.45 mg/dL; RBC:>100/HPF; UTP:3.79g; Renal biospy: IgAN | Steroid;dialysis | NA |
| Nakatani et al. | 47 | M | HTN | 19 days after 1st dose | mRNA | purpuric eruption | Proteinuria:3 +; occult blood :3 + Skin biopsy:IgA vasculitis Renal biospy: IgAN |
Steroid | PR |
F, female; M, male; IgAN, IgA nephropathy; F, female; M, male; HTP, hypertension; MH, microscopic hematuria; AH, asymptomatic hematuria; GH, gross hematuria; AKI, acute kidney injury; CKD, Chronic Kidney Disease; NS, nephrotic syndrome;RF, renal failure; KT, kidney transplantation; AAN, aristolochic acid nephropath; APS,antiphospholipid syndrome;UC, ulcerative colitis; MPGN type 1;membranous proliferative glomerulonephritis type 1; RF;rheumatoid arthritis; GDM, gestational diabetes mellitus; Scr, Serum creatinine; ALB, serum albumin; RBC, red blood cell; UTP,24-hurine protein;UPCR, urine protein-to-creatinine ratio; HD, hemodialysis; RASi,renin-angiotensin-aldosterone system inhibition;TPE, Therapeutic plasma exchange;N,none; CR, complete remission; PR, partial remission; NA, non-applicable; NR, no response;R, response.