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. Author manuscript; available in PMC: 2023 Apr 17.
Published in final edited form as: Mol Psychiatry. 2022 Aug 26;27(12):5213–5226. doi: 10.1038/s41380-022-01750-0

Fig. 8. The proposed model for KDM6B function in regulation of synaptic activity and cognition.

Fig. 8.

KDM6B interacts with Tau and is recruited by Tau to the promoters of Slc17a6 and Slc17a7, where it demethylates H3K27me3 to induce the expression of VGLUT1/2, leading to increased vesicle number, synaptic activity, dendritic spine density, and animal cognitive functions. KDM6B KO or Tau knockdown reduces VGLUT1/2 expression and vesicle number. Subsequently, it diminishes synaptic activity, spine density, and cognitive functions.