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. 2023 Mar 9;150(5):dev201231. doi: 10.1242/dev.201231

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© 2023. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Epithelial collapse in the EGFR mutant embryos. (A,B) Time-lapse imaging of ventral views of control (A) and EGFR-mutant (B) embryos carrying the junction marker Par6-GFP. Time (t)=0 was set at the time of salivary gland invagination (orange arrows). Times are in minutes. The site of the initial epithelial collapse in the EGFR mutant is marked with a white arrow (t=2 h). (C) Time course of the loss of junctional Par6-GFP localization. n=4 for each genotype. (D) Lateral view of the head of a control embryo. (E) An EGFR mutant embryo. Amnioserosa had already disintegrated at t=−30 min, followed by the loss of epithelial integrity at t=0 min. At t=60 min, the entire head region collapsed (n=5).