Table 2.
Comparison between hypogonadal and eugonadal patients prior to the start of mitotane.
| Hypogonadal patients (N=10) | Eugonadal patients (N=14) | p | ||
|---|---|---|---|---|
| BMI (kg/m2) | 25.0 (22.5-25.0) | 23.0 (21.0-27.0) | 0.787 | |
| Age at diagnosis (years) | 49.0 (41.5-57.0) | 54.5 (41.8-64.0) | 0.463 | |
| Smoking habit | Current smokers | 3 (30.0%) | 0 (0.0%) | 0.061 |
| Past smokers | 2 (20.0%) | 7 (50.0%) | 0.061 | |
| Alcohol habit | Regular drinkers | 2 (20.0%) | 5 (35.7%) | 0.243 |
| Occasional drinkers | 1 (10.0%) | 4 (28.6%) | 0.243 | |
| Secreting ACC | 5 (50.0%) | 5 (35.7%) | 0.423 | |
| Metastatic ACC | 6 (60.0%) | 9 (64.3%) | 0.825 | |
| Haemoglobin (g/dl) | 13.5 (11.7-15.4) | 13.6 (12.5-14.3) | 0.777 | |
| Haematocrit (%) | 41.1 (36.0-45.3) | 39.4 (37.6-42.7) | 0.549 | |
| Creatinine (mg/dl) | 0.7 (0.5-0.9) | 0.8 (0.7-1.1) | 0.139 | |
| TT (ng/ml) | 2.4 (1.4-3.1) | 5.5 (4.0-6.8) | 0.001 | |
| SHBG (nmol/l) | 53.0 (24.8-65.5) | 59.5 (30.3-71.5) | 0.663 | |
| cFT (pg/ml) | 65.3 (59.2-98.1) | 97.4 (69.6-121.4) | 0.125 | |
| E2 (pg/ml) | 25.0 (18.0-26.0) | 23.5 (12.8-32.0) | 0.764 | |
| Androstenedione (ng/ml) | 1.7 (0.9-3.6) | 0.8 (0.6-1.1) | 0.065 | |
| DHEAS (µg/ml) | 3.7 (1.4-6.5) | 0.3 (0.2-0.7) | 0.001 | |
| 17OH-P (ng/ml) | 3.4 (1.1-3.7) | 1.4 (1.2-1.7) | 0.073 | |
Data are expressed as median (IQR) for continuous variables and as absolute number (%) for categorical variables. A comparison between continuous variables was performed with Wilcoxon test; a comparison between categorical variables was performed with chi-square test. IQR, interquartile range; BMI, Body Mass Index; ACC, adrenocortical carcinoma; TT, total testosterone; SHBG, sex hormone binding globulin; cFT, calculated free testosterone; E2, estradiol; DHEAS, dehydroepiandrosterone; 17OH-P, 17-hydroxyprogesterone; significant data in bold.