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. 2023 Apr 17:1–15. Online ahead of print. doi: 10.1038/s41577-023-00858-w

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Fig. 2 — The large size of a human IgG neutralizing antibody (Protein Data Bank (PDB) ID: 1HZH) relative to the molecules that are involved in the entry of HIV into host cells — the viral envelope (Env) spike protein (PDB ID: 3J5M), and CD4 (PDB ID: 1WIO) and CCR5 (PDB ID: 1OPT) receptors on host cells — suggests that antibody can readily interfere with viral attachment to and/or fusion with the host cell through steric obstruction.